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| Name | Class |
|---|---|
| National Research Foundation of Korea | OTHER |
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Brain white matter hyperintensities (WMHs) are prevalent in migraineurs, of which the mechanism is still unclear. The investigators aimed to test the spatial association between areas with reduced cerebrovascular reactivity (CVR) to hypercapnic stimuli and consequent development of WMHs.
A whole-brain map of CVR will be created in patients with migraine and normal controls. Hypercapnic stimuli for CVR will be delivered by prospective end-tidal CO2 targeting device. Hemodynamic responses will be determined by BOLD signal changes using fMRI. WMHs will be determined by high-resolution 3D FLAIR imaging. Patients and controls will undergo serial MRIs with 1 year interval. Associations between areas of reduced CVR and consequent WMH development will be tested in both patients and controls.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Normal controls without headaches will undergo BOLD MRI with prospective CO2 targeting |
| |
| Migraineurs | Patients diagnosed with migraine based on the ICHD-3 beta will undergo BOLD MRI with prospective CO2 targeting |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| BOLD MRI | Diagnostic Test |
|
| Measure | Description | Time Frame |
|---|---|---|
| CVR association with WMH development | The investigators will obtain a CVR map using BOLD MR signal in the first year of study and also obtain changes in WMH during 2 years of follow-up period in patients and controls, respectively. Then the investigators will test whether CVR-map predicts consequent WMH development in patients and controls, respectively. | 1-year follow-up (2nd year) |
| Measure | Description | Time Frame |
|---|---|---|
| Spatial pattern of CVR | The investigators will obtain a CVR map for each voxel using BOLD MR signal in response to % increase in EtCO2 respectively in patients and controls. Spatial pattern of CVR will be compared between patients and controls. | baseline(1st year) |
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Inclusion Criteria:
Migraineurs(patients) :
Control:
Exclusion criteria:
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Controls and migraineurs who visited to a single university hospital
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| Name | Affiliation | Role |
|---|---|---|
| Mi Ji Lee, MD | Samsung Medical Center | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Samsung Medical Center | Seoul | South Korea |
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| ID | Term |
|---|---|
| D008881 | Migraine Disorders |
| ID | Term |
|---|---|
| D051270 | Headache Disorders, Primary |
| D020773 | Headache Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| D009422 | Nervous System Diseases |