Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 2015-A01982-47 | Other Identifier | ID-RCB |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Migraine with aura (MA) is an independent risk factor for stroke and is associated with silent brain infracts and T2 white matter hyperintensities on MRI. Previous studies using Transcranial Doppler (TCD) have shown an impairment of cerebral autoregulation in MA patients. Studies with positron emission tomography have demonstrated an activation of brain stem areas during migraine attack. An increased density of brain stem grey matter as measured on MRI with voxel based morphometry (VBM) has been found in MA patients. As brain arteries and arterioles are innervated by ascending tracts from aminergic brainstem nuclei, th study hypothesize a negative correlation between the density of brainstem nuclei and the efficiency of cerebral autoregulation in MA patients compared with controls.
Brainstem grey matter density will be studied with a MRI Philips 3 Tesla with a 32-channel antenna and voxel-based morphometry (VBM) cerebral autoregulation will be measured in the time domain using Transcranial Doppler (TCD) and the Mx method.
MA patients will be studied in a headache-free period. MRI and Transcranial Doppler (TCD) are non-invasive technics and will be performed on the same day.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Migraine with aura Patients | Other | Patients with migraine with aura will be studied 30 days after the pre inclusion visit with both magnetic resonance imaging and Transcranial Doppler. |
|
| Controls | Other | Control group with healthy volunteers will be studied 30 days after the pre inclusion visit with both magnetic resonance imaging and Transcranial Doppler. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Magnetic resonance imaging | Other | Patients and controls will first be studied with MRI. The total duration of MRI is about 60mn. These technic is not invasive. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between the density of the pontine grey matter evaluated with resonance magnetic imaging, and cerebral autoregulation measured with Transcranial Doppler in migraine with aura patients and controls. | Resonance magnetic imaging use voxel base morphometry and Transcranial doppler use the coefficient mx calculation. | 30 days after the pre-inclusion visit |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of brainstem grey matter density between migraine with aura patients and controls with magnetic resonance imaging | Comparison will be done with software using voxel based morphometry (VBM) function in addition of imaging with resonance magnetic imaging. | 30 days after pre-inclusion visit |
| Comparison of cerebral autoregulation between migraine with aura patients and controls with Transcranial Doppler |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Vincent LARRUE, MD | University Hospital, Toulouse | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Toulouse | Toulouse | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30296840 | Result | Gollion C, Nasr N, Fabre N, Barege M, Kermorgant M, Marquine L, Larrue V. Cerebral autoregulation in migraine with aura: A case control study. Cephalalgia. 2019 Apr;39(5):635-640. doi: 10.1177/0333102418806861. Epub 2018 Oct 8. | |
| 35982396 | Derived | Gollion C, Lerebours F, Nemmi F, Arribarat G, Bonneville F, Larrue V, Peran P. Insular functional connectivity in migraine with aura. J Headache Pain. 2022 Aug 19;23(1):106. doi: 10.1186/s10194-022-01473-1. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D020325 | Migraine with Aura |
| ID | Term |
|---|---|
| D008881 | Migraine Disorders |
| D051270 | Headache Disorders, Primary |
| D020773 | Headache Disorders |
| D001927 | Brain Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D009682 | Magnetic Resonance Spectroscopy |
| D017585 | Ultrasonography, Doppler, Transcranial |
| ID | Term |
|---|---|
| D013057 | Spectrum Analysis |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |
| D004453 | Echoencephalography |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Transcranial Doppler | Other | Patients and controls will first be studied with TCD. The total duration of TCD is about 60mn. These technic is not invasive. |
|
Comparison will be done using the calculation of mx coefficient in addition of imaging with Transcranial Doppler. |
| 30 days after pre-inclusion visit |
| Comparison of cerebrovascular reactivity to carbon dioxide between migraine with aura patients and controls with Transcranial Doppler | Comparison will be done using voluntary apnea test in addition of imaging with Transcranial Doppler. | 30 days after pre-inclusion visit |
| Comparison of morphological abnormalities between migraine with aura patients and controls with resonance magnetic imaging. | Comparison will be done using T2 white matter hyperintensities and silent brain infracts on resonance magnetic imaging. | 30 days after pre-inclusion visit |
| Comparison of baroreflex sensitivity between migraine with aura patients and controls with Transcranial Doppler | 30 days after pre-inclusion visit |
| Association between grey matter density and morphological abnormalities on resonance magnetic imaging | Association will be determined using T2 white matter hyperintensities, silent brain infracts and voxel based morphometry function of software | 30 days after pre-inclusion visit |
| Association between cerebral autoregulation and morphological abnormalities on magnetic resonance imaging | Association will be determined using T2 white matter hyperintensities, silent brain infracts and calculation of mx coefficient | 30 days after pre-inclusion visit |
| Relation between baroreflex sensitivity and cerebral autoregulation with Transcranial Doppler. | Relation will be determined using the calculation of mx coefficient in addition of imaging with Transcranial Doppler | 30 days after pre-inclusion visit |
| D002493 |
| Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D009485 | Neuroradiography |
| D059906 | Neuroimaging |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011859 | Radiography |
| D014463 | Ultrasonography |
| D018608 | Ultrasonography, Doppler |
| D003943 | Diagnostic Techniques, Neurological |