Migraine With Aura Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow by Hypoxia

Study of Migraine With Aura Inducing Characteristics and Effects on the Cerebral Arteries by Hypoxia in a Humane Experimental Migraine Model

In this study the investigators will investigate the following hypothesis

• that hypoxia induce migraine headache and migraine aura
• the aura phase is associated with a spreading reduction in cerebral blood flow
• the migraine headache is associated with dilatation of intra- and extracerebral arteries
• the migraine headache is associated with changes in brain metabolism
• the pre-ictal stage of a migraine attack with aura is associated with specific patterns in neural activity.

To investigate migraine with aura symptoms during and after hypoxia.

With magnetic resonance imaging the investigators will investigate changes in

• regional cerebral blood flow (rCBF)
• resting state functional connectivity
• circumference of the middle cerebral artery(MCA), internal carotic artery, superficial temporal artery, medial meningeal artery, external carotic artery
• brain metabolism

And compare these changes with a aged match healthy control group.

Inclusion Criteria:

Migraine with aura patients and Helthy volunteers as controls:

• Aged 18-40
• 50-100 kg

Exclusion Criteria:

• Tension type headache more than 5 days/month
• Other primary headaches
• Daily medication except contraceptives
• Drug taken within 4 times the halflife for the specific drug except contraceptives
• Pregnant or lactating women
• Headache or migraine attack within the last 48 hours before start of trial
• Hypertension
• Hypotension
• Respiratory or cardiac disease
• smoking

Extra exclusion Criteria for healthy volunteers:

• migraine at present or earlier in life
• parents, sibling or children who suffer or have suffered from migraine