The purpose of this research is to better understand brain white matter hyperintensities (WMH) in women with migraines

Inclusion Criteria - Migraine (N=20):

• Female only.
• Ages 20-45 years.
• Presence of WMH on MRI.

Exclusion Criteria:

• History of SVI and/or history of MS or other neurological disease other than migraine.
• History of cancer or organ transplantation.
• Contraindication to MRI.
• Pregnancy.
• History of abnormal brain MRI other than WMH.
• Subjects not willing to comply with the study procedures will be removed from the study.

Inclusion Criteria - SVI disease (n=10):

• Female only
• Ages > 60 years.
• Presence of WMH on MRI.

Exclusion Criteria:

• History of migraine and/or history of MS or other neurological disease other than SVI.
• History of cancer or organ transplantation.
• History of abnormal brain MRI other than WMH.
• Pregnancy.
• History of abnormal brain MRI other than WMH.
• Subjects not willing to comply with the study procedures will be removed from the study.

Inclusion Criteria - MS (n=10):

• Female only.
• Ages 20-45.
• Presence of WMH on MRI.

Exclusion Criteria:

• History of migraine and/or history of SVI or other neurological disease other than MS.
• History of cancer or organ transplantation.
• History of abnormal brain MRI other than WMH.
• Pregnancy.
• History of abnormal brain MRI other than WMH.
• Subjects not willing to comply with the study procedures will be removed from the study.