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The aim of this study is to investigate the effect of dual site-dual channel non-invasive brain stimulation for recovery of motor function in healthy subjects. Simultaneous dual site-dual channel stimulation was applied by using two sets of transcranial direct current stimulation devices. All subjects will go through four conditions of transcranial direct current stimulation with for 30 minutes. Four conditions are 1) Dual stimulation: i) anodal stimulation on right primary motor cortex and cathodal stimulation on left primary motor cortex, ii) anodal stimulation on right premotor cortex and cathodal stimulation on left supraorbital area. 2) M1 stimulation: anodal stimulation on right primary motor cortex and cathodal stimulation on left primary motor cortex; 3) PMC stimulation: anodal stimulation on right premotor cortex and cathodal stimulation on left supraorbital area. 4) sham stimulation
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dual stimulation | Experimental |
|
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| M1 stimulation | Experimental | anodal stimulation on right primary motor cortex and cathodal stimulation on left primary motor cortex |
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| PMC stimulation | Experimental | anodal stimulation on right premotor cortex and cathodal stimulation on left supraorbital area |
|
| Sham stimulation | Sham Comparator | Sham stimulation |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| M1 stimulation | Device | stimulating primary motor cortex with anodal stimulation on right primary motor cortex and cathodal stimulation on left primary motor cortex |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in motor evoked potential | measure the motor threshold and amplitude of motor evoked potential in first dorsal interosseous muscle | Baseline and after intervention (approximately 30 minutes) |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in sequential motor task | measures motor functional and dexterity of hand | Baseline and after intervention (approximately 30 minutes) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Samsung Medical Center | Seoul | South Korea |
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| PMC stimulation | Device | stimulating premotor cortex with anodal stimulation on right premotor cortex and cathodal stimulation on left supraorbital area |
|
| Sham stimulation | Device | sham stimulation over both primary motor cortex and premotor cortex |
|