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The aim of this study is to investigate the effect of dual site-dual channel non-invasive brain stimulation for recovery of motor function in post stroke patients. Simultaneous dual site-dual channel stimulation was applied by using two sets of transcranial direct current stimulation devices. All subjects will go through three conditions of transcranial direct current stimulation with for 30 minutes. Three conditions are 1) Dual stimulation 1: i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional premotor cortex and cathodal stimulation on contralesional supraorbital area. 2) Dual stimulation 2: i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional anterior intraparietal sulcus and cathodal stimulation on contralesional supraorbital area. 3) Single stimulation: anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dual Stimulation 1 | Experimental | i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional premotor cortex and cathodal stimulation on contralesional supraorbital area. |
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| Dual Stimulation 2 | Experimental | i) anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex, ii) anodal stimulation on ipsilesional anterior intraparietal sulcus and cathodal stimulation on contralesional supraorbital area. |
|
| Single stimulation | Experimental | anodal stimulation on ipsilesional primary motor cortex and cathodal stimulation on contralesional primary motor cortex |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| M1 stimulation | Device | stimulating primary motor cortex with anodal transcranial direct current stimulation |
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| Measure | Description | Time Frame |
|---|---|---|
| Changes in motor evoked potentia | measure the motor threshold and amplitude of motor evoked potential in first dorsal interosseous muscle. | Baseline and after intervention (approximately 2 weeks) |
| Measure | Description | Time Frame |
|---|---|---|
| changes in nine hole peg test | Nine-Hole Peg Test is used to measure finger dexterity in patients with various neurological diagnoses. | Baseline and after intervention (approximately 2 weeks) |
| changes in grip and tip pinch strength test |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Samsung Medical Center | Seoul | South Korea |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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|
| PMC stimulation | Device | stimulating premotor cortex with anodal transcranial direct current stimulation |
|
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| aIPS stimulation | Device | stimulating anterior intraparietal sulcus with anodal transcranial direct current stimulation |
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| hand motor task | Behavioral | hand motor task for 30 minutes during transcranial direct current stimulation |
|
measure the hand strength (grip and tip pinch)
| Baseline and after intervention (approximately 2 weeks) |
| changes in box and block test | box and block test measures unilateral gross manual dexterity | Baseline and after intervention (approximately 2 weeks) |
| Changes in brain activation of resting-state functional MRI | Neuroplasticity measure | Baseline and after intervention (approximately 2 weeks) |
| Changes of Cortical activation | Cortical activation is measured by functional Near-Infrared-Spectroscopy (fNIRS) (NIRScout, NIRx, Germany) | Baseline and after intervention (approximately 2 weeks) |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |