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The aim of this study is to investigate the effect of dual site-dual channel non-invasive brain stimulation for recovery of language and cognitive function in post stroke patients. Simultaneous dual site-dual channel stimulation was applied by using two sets of transcranial direct current stimulation devices. All subjects will go through four conditions of transcranial direct current stimulation with for 30 minutes. Four conditions are 1) Dual stimulation: i) anodal stimulation on ipsilesional inferior frontal cortex, ii) anodal stimulation on ipsilesional dorsolateral prefrontal cortex. 2) Single stimulation 1: anodal stimulation on ipsilesional inferior frontal cortex and cathodal stimulation on contralesional inferior frontal cortex; 3) Single stimulation 2: anodal stimulation on ipsilesional inferior frontal cortex and cathodal stimulation on contralesional supraorbital area.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dual stimulation | Active Comparator | i) anodal stimulation of ipsilesional inferior frontal cortex and cathodal stimulation of contralesional supraorbital area ii) anodal stimulation on ipsilesional dorsolateral prefrontal cortex and cathodal stimulation of contralesional supraorbital area |
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| Single stimulation 1 | Active Comparator | i) anodal stimulation of ipsilesional inferior frontal cortex and cathodal stimulation of contralesional inferior frontal cortex |
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| Single stimulation 2 | Active Comparator | i) anodal stimulation of ipsilesional inferior frontal cortex and cathodal stimulation of contralesional supraorbital area |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| IFG stimulation | Device | stimulating inferior frontal cortex with transcranial direct current stimulation for 30 minutes |
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| Measure | Description | Time Frame |
|---|---|---|
| Changes in Korean Boston naming test | measures naming ability thorough picture naming test | Baseline and after intervention (approximately 2 weeks) |
| Changes in Korean Western Aphasia Battery | assessment of language function and provide aphasia quotients | Baseline and after intervention (approximately 2 weeks) |
| Measure | Description | Time Frame |
|---|---|---|
| Digit span test | measures memory span | Baseline and after intervention (approximately 2 weeks) |
| Korea Montreal Cognitive Assessment | measure cognitive function |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Samsung Medical Center | Seoul | South Korea |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| D001037 | Aphasia |
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| DLPFC stimulation | Device | stimulating dorsolateral prefrontal cortex with transcranial direct current stimulation for 30 minutes |
|
| aphasia therapy | Behavioral | aphasia therapy for 30 minutes during transcranial direct current stimulation |
|
| Baseline and after intervention (approximately 2 weeks) |
| Korean Color Word Stroop test | measures selective attention and executive function | Baseline and after intervention (approximately 2 weeks) |
| Controlled Oral Word Association Test | measure verbal fluency | Baseline and after intervention (approximately 2 weeks) |
| Changes of Cortical activation | Cortical activation is measured by functional Near-Infrared-Spectroscopy (fNIRS) (NIRScout, NIRx, Germany) | Baseline and after intervention (approximately 2 weeks) |
| Changes in brain activation of resting-state and task functional MRI | Neuroplasticity measure | Baseline and after intervention (approximately 2 weeks) |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D013064 | Speech Disorders |
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |