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| Name | Class |
|---|---|
| Menssana Research, Inc. | INDUSTRY |
| Aurametrix | OTHER |
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The purpose of this secondary analysis is to identify breath signatures associated with idiopathic malodor conditions.
Individuals with metabolic disorders may sporadically produce malodors despite good hygiene. Analysis of volatile organic compounds (VOCs) helps to gain insights into medical conditions arising due to metabolic dysfunction as different metabolic pathways emit and or consume various VOCs. These VOCs can be detected via the exhaled breath collected and analyzed with a portable breath collection apparatus. VOC profiles will be compared with self-reported symptoms and other observations of participating subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Body odor | individuals self-reporting idiopathic body odor with or without bad breath |
| |
| Breath odor | individuals self-reporting idiopathic bad breath but no body odor |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Breath test | Other | Breath samples taken from all participants, analyzed with gas chromatography mass spectrometry (GC/MS), no treatment given. |
|
| Measure | Description | Time Frame |
|---|---|---|
| VOCs detected | Expired air sample drawn principally from alveolar breath is analyzed by gas chromatography-mass spectrometry. Chromatograms are searched against the NIST library. The response for each analyte is normalized by using internal standards containing 1-bromo-4-fluoro-benzene. | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Correlations between breath biomarkers and self-reported observations (questionnaires) | VOC profiles will be compared with self-reported symptoms, observed exposures and other observations of participating subjects. Volatile organic compounds differentiating the disease activity will be identified. | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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Individuals self-reporting idiopathic malodor production as a consequence of a systemic disorder
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| Name | Affiliation | Role |
|---|---|---|
| Irene Gabashvili, PhD | MeBO Research | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| MeBO Research | Miami | Florida | 33175 | United States | ||
| MeBO Research LTD |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 9177688 | Background | Phillips M. Method for the collection and assay of volatile organic compounds in breath. Anal Biochem. 1997 May 1;247(2):272-8. doi: 10.1006/abio.1997.2069. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Apr 18, 2024 | |
| Reset | Sep 12, 2024 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Apr 18, 2024 | Sep 12, 2024 |
| ID | Term |
|---|---|
| D009750 | Nutritional and Metabolic Diseases |
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|
| London |
| England |
| W10 5LE |
| United Kingdom |