Exploratory Study of Relationships Between Malodor and Urine Metabolomics

Metabolomic Profiling of Urine Samples for the Identification of Novel Biomarkers and Mechanisms in the Diagnosis and Management of Malodor Associated With Metabolic Inefficiencies

The purpose of this study is to identify metabolic signatures associated with malodor conditions. The investigators will perform state-of-the art metabolomics tests and bioinformatic data mining to explore if conditions leading to malodor can be screened by metabolomic profiling of urine samples.

In this study, metabolite profiling analysis will be carried out on urine samples of individuals with malodor conditions related to metabolism inefficiencies. Metabolic profiles will be identified using the metabolomics equipment located in the NMR, HPLC and MS facilities of the Metabolomics Innovation Centre (TMIC). Multivariate statistical analyses will be used, as well as other approaches to mine complex data from heterogeneous sources.

Inclusion Criteria:

• 18 years or older
• unpredictable and uncontrollable episodes of malodor
• willing and able to ship a urine sample (in the kit provided) by an overnight courier to Edmonton, Alberta, Canada
• good general health

Exclusion Criteria:

• serious medical conditions that require treatment
• conditions that, in the opinion of the investigator, would prevent participation
• under the age of 18
• elect not to participate in the study