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Detection of Colorectal and Pancreatic Cancers Using Breath Analysis - Feasibility Study
A diagnostic prospective study with no anticipated risks or constraints. Main Objective: To quantify differences in exhaled breath VOCs of patients with colorectal or pancreatic cancers compared with cohorts without cancer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Colorectal Cancer | Experimental | Subjects who were diagnosed as Colorectal Cancer patients by colonoscopy. |
|
| Pancreatic Cancer | Experimental | Subjects who were diagnosed as Pancreatic Cancer patients by Endoscopic Retrograde Cholangio Pancreatography. |
|
| Healthy volunteers | Other | Subjects who were found with no Colorectal or Pancreatic malignancies, by either colonoscopy or by Endoscopic Retrograde Cholangio Pancreatography. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| VOX | Diagnostic Test | Breath Biopsy Analysis |
|
| Measure | Description | Time Frame |
|---|---|---|
| identification of Volatile Organic Compounds that can be related to Colorectal malignancy. | Comparison of identity and concentration of Volatile Organic Compounds profile found among colorectal patients and the identity and concentration of Volatile Organic Compounds profile found among Healthy controls. | Through the study completion, up to 1 year. |
| Measure | Description | Time Frame |
|---|---|---|
| Test Sensitivity and specificity for colorectal polyps. | Comparison of Volatile Organic Compounds found among subjects with and without colorectal polyps. | Through the study completion, up to 1 year. |
| Test Sensitivity and specificity for pancreatic cancer. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| HAREL HERSHTIK | Contact | 0546641812 | harel.hershtik@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Haim Shirin, MD | Assaf-Harofeh Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shamir Medical Center | Be’er Ya‘aqov | Israel |
No IPD is to be shared with other researchers.
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| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D010190 | Pancreatic Neoplasms |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
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Parallel Assignment
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Comparison of Volatile Organic Compounds found among pancreatic patients and Healthy controls. |
| Through the study completion, up to 1 year. |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| D004701 | Endocrine Gland Neoplasms |
| D010182 | Pancreatic Diseases |
| D004700 | Endocrine System Diseases |