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The purpose of this study is to investigate whether there are differences in postprandial cardiometabolic metabolic indices following interesterified fats used commercially versus application appropriate non- interesterifed alternative fat.
Aim: The current study aims to investigate the acute effects of commercially available interesterified fat versus versus application appropriate non- interesterifed alternative fat on 8 h postprandial cardiometabolic outcomes.
Hypothesis: Interesterified fat will induce a different cardiomtabolic response compared to a non interesterifed, application appropriate fat.
Subjects: Participants will include 40 healthy male and female volunteers aged between the ages of 35 and 75 years (since during this age metabolic changes start to take place).
Power calculation: Based on previous studies carried out by our group at King's College London, a sample size of 20 participants (males and females separately) will allow a 2.16% (percentage unit) difference in FMD to be detected (90% power, 0.05 alpha, SD 2.9. 50 participants will be recruited allowing for a 20% dropout rate.
Expected value:The study will provide novel information on the acute effects of commercially relevant processed fats on postprandial lipaemia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Interesterified | Experimental | Commercially available interesterifed fat spread. 50g fat. |
|
| Non- interesterified | Active Comparator | Commercially available non-interesterified fat. 50g fat. |
|
| Control | Active Comparator | Rapeseed oil. 50 g fat. |
|
| Saturated fat control | Active Comparator | Butter. 50g fat |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Interesterified fat | Dietary Supplement | 50 g fat provided as commercially available interesterified fat. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Endothelial function | Flow mediated dilatation | Up to 8 hours |
| Postprandial lipaemic response | Area under plasma TAG concentration/ time curve | Up to 8 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Postprandial lipaemic response | Postprandial plamsa total fatty acid composition and non esterifed fatty acid | Up to 8 hours |
| Metabolomic for assessment of atherogenic potential (lipoprotein) analysis |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Nutritional Sciences, Faculty of Life Sciences and Medicine, Kings College London | London | SE1 9NH | United Kingdom | |||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38380649 | Derived | Hall WL, Alkoblan A, Gibson PS, D'Annibale M, Coekaerts A, Bauer M, Bruce JH, Lecomte B, Penhoat A, Laugerette F, Michalski MC, Salt LJ, Wilde PJ, Berry SE. Postprandial lipid and vascular responses following consumption of a commercially-relevant interesterified palmitic acid-rich spread in comparison to functionally-equivalent non-interesterified spread and spreadable butter: a randomised controlled trial in healthy adults. Food Funct. 2024 Mar 4;15(5):2733-2750. doi: 10.1039/d3fo05324e. |
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| ID | Term |
|---|---|
| D000074262 | Rapeseed Oil |
| D002079 | Butter |
| ID | Term |
|---|---|
| D010938 | Plant Oils |
| D009821 | Oils |
| D008055 | Lipids |
| D028321 | Plant Preparations |
| D001688 |
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| Non- interesterified fat | Dietary Supplement | 50 g fat provided as commercially available non-interesterified fat. |
|
| Rapeseed oil | Dietary Supplement | 50 g fat provided as commercially available rapeseed oil. |
|
| Butter | Dietary Supplement | 50g fat provided as commercially available spreadable butter |
|
Lipid concentrations and compositions of 14 lipoprotein subclasses, measured by NMR
| Up to 8 hours |
| Glycaemic response | Plasma glucose concentration | Up to 8 hours |
| Insulinaemic response | Plasma insulin concnetration | Up to 8 hours |
| Nitric oxide bioavailability | Plasma nitric oxide species and NADPH oxidase activity | Up to 8 hours |
| Oxidative stress | Plasma 8-isoprostane F2a | Up to 8 hours |
| Inflammatory response | Plasma IL-6 | Up to 8 hours |
| King's College London |
| London |
| SE1 9NH |
| United Kingdom |
| Biological Products |
| D045424 | Complex Mixtures |
| D004041 | Dietary Fats |
| D005223 | Fats |
| D003611 | Dairy Products |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |