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The purpose of the study is to examine the effect of consuming 50g of fat from 5 different sources (coconut, canola, grapeseed, chia, and butter) on arterial stiffness, blood pressure and blood glucose levels. It is hypothesized that butter will have the most detrimental effect on acute vascular function. Canola, grapeseed and chia oil with their decreased content of SFA are hypothesized to impair vascular function to a lesser extent.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Coconut oil | Experimental |
| |
| Canola oil | Experimental |
| |
| Grapeseed oil | Experimental |
| |
| Chia oil | Experimental |
| |
| Butter | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Coconut Oil | Other | Shake with 50 g Coconut oil |
|
| Measure | Description | Time Frame |
|---|---|---|
| To compare 5 different dietary fat sources in a liquid meal on postprandial changes in augmentation index (AIx) | 5 separate mornings, measurements taken at baseline and at 60, 120 and 180 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| To investigate whether these dietary fat sources will result in blood pressure changes and a differential glycemic response | 5 separate mornings, blood pressure measurements will be taken at baseline, 60, 120 and 180 minutes. Blood samples will be taken at baseline 15, 30, 45, 60, 90 and 120 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Thanh Ho, BSc | Contact | 416-864-6060 | 2087 | hoho@smh.ca |
| Name | Affiliation | Role |
|---|---|---|
| Vuksan Vladimir, PhD | Risk Factor Modification Centre - St. Michael's Hospital | Principal Investigator |
| Alexandra Jenkins (Co-investigator), PhD, RD | Unity Health Toronto | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Risk Factor Modification Centre, St. Michael's Hospital | Recruiting | Toronto | Ontario | M5B 1W8 | Canada |
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| ID | Term |
|---|---|
| D000074263 | Coconut Oil |
| D000074262 | Rapeseed Oil |
| C000715327 | Salvia hispanica seed extract |
| D002079 | Butter |
| ID | Term |
|---|---|
| D004041 | Dietary Fats |
| D005223 | Fats |
| D008055 | Lipids |
| D010938 | Plant Oils |
| D009821 |
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| Canola Oil | Other | Shake with 50 g Canola oil |
|
| Grapeseed Oil | Other | Shake with 50 g Grapeseed oil |
|
| Chia Oil | Other | Shake with 50 g Chia oil |
|
| Butter | Other | Shake with 50 g Butter |
|
| William Watson (Qualified investigator), MD | Unity Health Toronto | Principal Investigator |
| Elena Jovanovski (Co-investigator), MSc | Unity Health Toronto | Principal Investigator |
| Oils |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
| D003611 | Dairy Products |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |