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| Name | Class |
|---|---|
| British Broadcasting Corporation | INDUSTRY |
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This is a randomised trial in which healthy volunteers, men and women aged 50-75 years from the general community are randomized into one of three arms: participants will be provided with 50 gm extra virgin coconut oil,or 50 grams butter or 50 extra virgin olive oil to be eaten daily for a month. The key outcome is blood low density lipoprotein cholesterol concentrations and secondary outcomes blood lipid profile (total cholesterol, high density lipoprotein cholesterol, triglycerides) and anthropometric measures: weight and waist circumference. This trial is powered to detect a difference of 0.5 mmol/L LDL-cholesterol difference between the trial arms.
This is a randomized trial in which healthy volunteers from the general community are randomized into one of three arms: consumption of 50 gm of extra virgin coconut oil daily OR 50gm of butter daily OR 50gm of extra virgin olive oil daily (50gm is about 2 ounces, or 2 table spoons), to be consumed over a one month period.
The research participants will be recruited from the general community through advertising (BBC).
After full informed consent, participants will attend an assessment visit and have a baseline measures of weight, height, waist circumference, blood pressure, a blood sample for assessment of blood lipids and other metabolic markers, and fill in a health questionnaire and dietary questionnaire. Participants will be randomly allocated to one of three arms: coconut oil, butter or olive oil and will be given supplies of these (portioned, or with measuring spoons) with information about daily consumption of 50 gram of one of these fats.
After one month, participants will return for follow up assessment which will include a repeat blood sample, anthropometric measures and blood pressure, and questionnaire.
Blood samples collected by venepuncture will be stored at the University of Cambridge and analysed at the Department of Clinical Biochemistry, Cambridge University Addenbrooke's Hospital.
At the end of the study, all participants will be given the individual participant results of the anthropometric measures and lipid profiles at baseline and follow up as well as the overall findings of the trial.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Coconut oil | Active Comparator | 50g extra virgin coconut oil to be consumed daily for four weeks |
|
| Butter | Active Comparator | 50g butter to be consumed daily for four weeks |
|
| Olive Oil | Active Comparator | 50g extra virgin olive oil to be consumed daily for four weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Coconut oil | Other | 50g extravirgin coconut oil daily for four weeks |
| |
| Measure | Description | Time Frame |
|---|---|---|
| LDL-Cholesterol | Blood LDL cholesterol concentrations | after 4 weeks of the dietary fat interventions |
| Measure | Description | Time Frame |
|---|---|---|
| triglycerides | Blood triglycerides | after 4 weeks of the dietary fat interventions |
| HDL-Cholesterol | blood HDL-Cholesterol | after 4 weeks of the dietary fat interventions |
| Measure | Description | Time Frame |
|---|---|---|
| Inflammatory markers | Blood inflammatory markers C-Reactive protein | after four weeks of the dietary fat interventions |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kay-Tee Khaw, MBBChir | University of Cambridge | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Cambridge | Cambridge | CB2 2QQ | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29511019 | Derived | Khaw KT, Sharp SJ, Finikarides L, Afzal I, Lentjes M, Luben R, Forouhi NG. Randomised trial of coconut oil, olive oil or butter on blood lipids and other cardiovascular risk factors in healthy men and women. BMJ Open. 2018 Mar 6;8(3):e020167. doi: 10.1136/bmjopen-2017-020167. |
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Anonymised IPD data from the trial will be available at the end of the study with publication of the results, through contact with the principal investigator
Once trial report published; anticipated March 2018
Bona fide researchers
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| ID | Term |
|---|---|
| D000074263 | Coconut Oil |
| D002079 | Butter |
| D000069463 | Olive Oil |
| ID | Term |
|---|---|
| D004041 | Dietary Fats |
| D005223 | Fats |
| D008055 | Lipids |
| D010938 | Plant Oils |
| D009821 |
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Randomized trial of different dietary fats
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The primary outcome will be blood LDL-cholesterol, secondary outcomes, lipid profile which will be measured in a biochemistry lab by individuals who have no knowledge of the allocation to intervention arms.
| Butter |
| Other |
50g butter daily for four weeks |
|
| Olive oil | Other | 50g extra virgin olive oil daily for four weeks |
|
| total cholesterol | blood total Cholesterol | after 4 weeks of the dietary fat interventions |
| weight | weight | after four weeks of the dietary fat interventions |
| waist circumference | Waist circumference | after four weeks of the dietary fat interventions |
| Systolic Blood pressure | systolic blood pressure | after four weeks of the dietary fat interventions |
| Oils |
| D003611 | Dairy Products |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |
| D004042 | Dietary Fats, Unsaturated |
| D005224 | Fats, Unsaturated |