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Gut hormones have therapeutic potential in the prevention and treatment obesity and type 2 diabetes (T2D). Rodent evidence suggests that calcium may stimulate gut hormone secretion. Evidence in humans however, is lacking. This study aims to assess whether the calcium ingestion stimulates gut hormone availability in humans.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Placebo Comparator | Water with artificial sweetener |
|
| Milk mineral supplement | Experimental | Milk Minerals containing 1000 mg calcium with artificial sweetener and water |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Control | Dietary Supplement | Water with 80 mg sucralose |
| |
| Milk mineral supplement |
| Measure | Description | Time Frame |
|---|---|---|
| Postprandial plasma GLP-1 area under the curve (mmol/L x 120 min). | Postprandial plasma GLP-1 area under the curve (mmol/L x 120 min). | 120 min |
| Measure | Description | Time Frame |
|---|---|---|
| Postprandial plasma GIP area under the curve (mmol/L x 120 min) | Postprandial plasma GIP area under the curve (mmol/L x 120 min) | 120 min |
| Postprandial plasma PYY area under the curve (mmol/L x 120 min) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department for Health, University of Bath | Bath | BA2 7AY | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31531707 | Derived | Chen YC, Smith HA, Hengist A, Chrzanowski-Smith OJ, Mikkelsen UR, Carroll HA, Betts JA, Thompson D, Saunders J, Gonzalez JT. Co-ingestion of whey protein hydrolysate with milk minerals rich in calcium potently stimulates glucagon-like peptide-1 secretion: an RCT in healthy adults. Eur J Nutr. 2020 Sep;59(6):2449-2462. doi: 10.1007/s00394-019-02092-4. Epub 2019 Sep 17. |
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Share anonymised data in publication form
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| Dietary Supplement |
Water with milk mineral supplement (1000 mg calcium), plus 80 mg sucralose |
|
Postprandial plasma PYY area under the curve (mmol/L x 120 min)
| 120 min |
| Subjective ratings of appetite (au) | Subjective ratings of appetite (au) | 120 min |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D004700 | Endocrine System Diseases |