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The purpose of this study is to investigate the appetite, insulin and incretin hormone responses to a high-calcium meal.
Participants will be provided with control and high-calcium meals. Insulin, appetite, glucagon-like peptide-1 and glucose-dependent insulinotropic peptide responses will be assessed, along with rates of substrate oxidation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | Breakfast consisting of milk-based porridge with a normal calcium content. | |
| High-Calcium | Experimental | As control, but with a high-calcium content. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Calcium | Dietary Supplement | Milk-calcium supplement |
|
| Measure | Description | Time Frame |
|---|---|---|
| Subjective appetite ratings | Subjective ratings of appetite assessed by visual analogue scales. | 3 hour |
| Measure | Description | Time Frame |
|---|---|---|
| Serum insulin concentration | 2 hour area under the curve for serum insulin following breakfast consumption | 2 hour |
| Plasma glucose-dependent insulinotropic peptide concentration | 2 hour area under the curve for plasma glucose-dependent insulinotropic peptide following breakfast consumption |
| Measure | Description | Time Frame |
|---|---|---|
| Total fat oxidised during 60 min of exercise (g) | Assessed by indirect calorimetry | 1 hour |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Javier T Gonzalez, MRes | Northumbria University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Northumbria University | Newcastle upon Tyne | Tyne on Wear | NE1 8ST | United Kingdom |
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| ID | Term |
|---|---|
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D002118 | Calcium |
| ID | Term |
|---|---|
| D008673 | Metals, Alkaline Earth |
| D004602 | Elements |
| D007287 | Inorganic Chemicals |
| D008670 | Metals |
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| 2 hour |
| Plasma glucagon-like peptide-1 concentration | 2 hour area under the curve for plasma glucagon-like peptide-1 following breakfast consumption | 2 hour |
| D001779 |
| Blood Coagulation Factors |
| D001685 | Biological Factors |