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The aims of the study are 1) to compare the differences in plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances in athletes (i.e., soccer, and taekwondo players) and healthy non-athletes; 2) to investigate the relationship between plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances; 3) to explore the influence on plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances after 12 weeks of coenzyme Q10 intervention (150 mg/day and 300 mg/day).
The long-term high-amount and -intensity exercise training could cause oxidative damage, muscle impairment, inflammation and exercise fatigue to athletes easily. Such above conditions will affect the exercise performances and health of athletes. The aims of the study are 1) to compare the differences in plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances in athletes (i.e., soccer, and taekwondo players) and healthy non-athletes; 2) to investigate the relationship between plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances; 3) to explore the influence on plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances after 12 weeks of coenzyme Q10 intervention (150 mg/day and 300 mg/day). Eventually, these results of this study can provide the information for the known to improve the oxidative stress, anti-oxidation and inflammation internal to the bodies of athletes for various competitions. As a consequence, the athletic performances can be further enhanced.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Experimental | Placebo |
|
| Q10-150 | Experimental | coenzyme Q10 150 mg/d. |
|
| Q10-300 | Experimental | coenzyme Q10 300 mg/d. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Other | Placebo (dextrin) |
| |
| Coenzyme Q10 |
| Measure | Description | Time Frame |
|---|---|---|
| malondialdehyde (MDA) | MDA (micromol/L) will measure by thiobarbituric acid reacting substance. | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Antioxidant capacity | Total antioxidant capacity (TAC) was measured by a Trolox equivalent antioxidant capacity assay in serum and erythrocytes. | 12 weeks |
| high sensitivity C-reactive protein (hs-CRP) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chung Shan Medical University | Taichung | 40201 | Taiwan |
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placebo-control
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| Dietary Supplement |
150 mg or 300 mg |
|
hs-CRP will measure by immunoturbidimetry.
| 12 weeks |
| creatine kinase (CK) | serum CK will measure by enzymatic method. | 12 weeks |
| Lactate dehydrogenase (LDH) | serum LDH will measure by enzymatic method. | 12 weeks |
| one-repetition maximum (1-RM) | 1RM measurements will report in kilograms for data analysis. | 12 weeks |
| Glucose | mmol/L | 12 weeks |
| HbA1C | HbA1C will measure by an automated glycated hemoglobin analyzer | 12 weeks |
| Insulin | insulin will measure by an automated chemistry analyzer | 12 weeks |
| ID | Term |
|---|---|
| C024989 | coenzyme Q10 |
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