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The goal of this clinical trial is to learn if CoQ10 amplifies endurance training-induced myokine and exerkine secretion and if those changes influences cognition in long-distance runners.
Does 4-week high-dosage CoQ10 supplementation increase the secretion of myokine, exerkine sercetion? Does the above-mentioned intervention improve the cognitive function in long distance runners?
Participants will:
Take CoQ10 or a placebo every day for 4 weeks. Visit the laboratory once every 4 weeks for checkups and tests. Keep the participants' food and training diary.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CoQ10-treated participants | Experimental | The participants will be treated with CoQ10 supplements |
|
| Placebo-treated participants | Placebo Comparator | The participants will be treated with placebo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CoQ10 supplementation | Dietary Supplement | Long-distance runners will be supplemented with CoQ10 for 4 weeks in cross-over manner with 4 weeks of wash out period. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in cognitive funtions as a result of CoQ10 supplementation measured via cogntitive function test. | The investigators assume that supplementation with CoQ10 will change cognition (measured via cognitive function tests - Stroop Test, Trial Making Test A and Trial Making Test B) in long-distance runners. The results will be obtained as time (seconds) needed to complete tasks while testing. | The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10 |
| Change in myokine and exerkine concentration in the blood plasma as a result of CoQ10 supplementation. | The investigators will assess the concentration of blood myokine and exerkine concentration (pg or ug/dl) of blood plasma using the colorimetric method. | The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10 |
| Measure | Description | Time Frame |
|---|---|---|
| Change in aerobic capacity measured via direct test to volitional exhaustion on a motorized treadmill | The investigators assume that supplementation with CoQ10 will change the aerobic capacity (oxygen uptake in ml-1 x min-1 x kg-1) in long-distance runners. The determination of aerobic capacity will be done through progressive test to volitional exhaustion on a motorized treadmill and gas analyzer |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gdansk University of Physical Education and Sport | Recruiting | Gdansk | 80-333 | Poland |
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A randomized, double-blind, placebo-controlled, cross-over study
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| Placebo supplementation | Dietary Supplement | Long-distance runners will be supplemented with placebo for 4 weeks in cross-over manner with 4 weeks of wash out period. |
|
| The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10 |
| ID | Term |
|---|---|
| D001519 | Behavior |
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