The Effects of Dietary Supplement of Coenzyme Q10（CoQ10） on Dyslipidemia

The Effects of Dietary Supplement of Coenzyme Q10 on Dyslipidemia

In previous study the investigators found that CoQ10 can improve cholesterol efflux from macrophages in cell model, ApoE mice model and small-scale of healthy volunteers. In addition, CoQ10 has strong antioxidant activity and is an essential factor of mitochondria electron transport chain. So the investigators hypothesize that CoQ10 may have some health promotion effect on dyslipidemia, risk factor of atherosclerosis and other cardiovascular diseases. On this purpose, the investigators are going to recruit 150 dyslipidemia patients to supply CoQ10+vitamin E or CoQ10 alone or placebo in different doses for 24 weeks to explore the effects of CoQ10 on cholesterol efflux and lipid profiles on dyslipidemia.

Inclusion Criteria:

• The subjects were considered to have dyslipidemia if they met 2 of the following 4 criteria:

  • fasting total cholesterol concentration>200 mg/dL,
  • fasting triglyceride concentration>150mg/dL,
  • fasting LDL-cholesterol concentrations>100 mg/dL, or
  • fasting HDL-cholesterol concentrations>40 mg/dL.

Exclusion Criteria:

• history of CVD or other severe chronic disease or use of any drugs known to affect lipid metabolism.
• use any antioxidant such as Vitamin E, vitamin C,Phytochemicals and coenzyme Q10 within two months before trial.
• pregnant or lactating women