Anti-adhesive Effect and Safety of "Thermo-sensitive Adhesion Barrier (MEDICLORE)"

Anti-adhesive Effect and Safety of "Thermo-sensitive Adhesion Barrier (MEDICLORE)" by Using Double-blind Test in Thyroid Surgery

One of most important complication of thyroid surgery is adhesion. There are many anti-adhesive materials, but none of them showed significant outcomes. The investigators planned double blind prospective study of "Thermo-sensitive Adhesion Barrier (MEDICLORE)" to reveal anti-adhesive effect of MEDICLORE. The investigators will recruit total 90 patients (control group 45, experimental group 45) and compare postoperative outcomes about adhesion.

Inclusion Criteria:

• planned to perform thyroidectomy due to thyroid nodule
• no evidence of distant metastasis or invasion to adjacent organ in thyroid cancer
• normal preoperative vocal cord movement
• normal preoperative laboratory study

Exclusion Criteria:

• uncontrolled hypertension, diabetes, chronic renal failure, coagulopathy
• history of keloid or hypertrophic scar
• Graves disease or hashimoto thyroiditis patients
• aspirin or anticoagulant medication within 7 days
• radiation exposure to the head and neck
• previous operation to the neck
• history of allergic reaction to drugs
• pregnant women