A Comparative Study of Sibling Oocytes: ICSI vs. the PICSI Sperm Selection Method

A Comparative Study of Sibling Oocytes, Which Examines Two Sperm Selection Methods for Top Quality of Spermatozoa , Prior Intracytoplasmic Sperm Injection (ICSI) Performance, and Their Effect on Embryo Quality and IVF Outcome: A Common Selection Method Based on Morphology (ICSI) vs. a Selection Method for Mature Spermatozoa With CD44 Receptors for Hyaluronic Acid (PICSI - Physiological Selected Intracytoplasmic Sperm Injection)

The aim of this research is to compare sibling oocytes using two sperm selection methods for choosing the best quality spermatozoa before they are injected into oocytes and the influence of each of these methods on embryo quality and IVF outcome.

Inclusion Criteria:

• Males aged 18-60
• Females aged 18-35
• Males with mild OTA (oligo terato astheno zoospermia) and at least one failed IVF cycle
• Males with normozoospermia with at least 2 unexplained failed IVF cycles
• Females with normal FSH and normal AMH values
• Females who have retrieved in previous cycles at least 6 oocytes

Exclusion Criteria:

• Couples who have been exposed to heavy smoking, drugs and chronic diseases
• Males who have undergone testicular surgery (TESE) or defined as severe OTA
• Females with egg factor infertility