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The aim of this research is to compare sibling oocytes using two sperm selection methods for choosing the best quality spermatozoa before they are injected into oocytes and the influence of each of these methods on embryo quality and IVF outcome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ICSI Procedure | Active Comparator | The ICSI procedure is the standard procedure of selection and injection of sperm into the oocyte using a standard ICSI petri dish. |
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| PICSI Procedure | Active Comparator | The PICSI procedure is based on a selection of mature spermatozoa with CD44 receptors and their injection into the oocyte using the PICSI petri dish that has been coated with hyaluronic acid on its bottom. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ICSI petri dish | Device | Half of the oocytes will be placed into the standard ICSI petri dish and they will be injected with sperm with normal morphology. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of fertilization rate | Injected sibling oocytes are incubated in a time-lapse incubator which enables ongoing observation after fertilization and cleavage of each oocyte. The fertilization rates of the ICSI and PICSI methods will be compared. | Three years |
| Comparison of embryo quality | Injected sibling oocytes are incubated in a time-lapse incubator which enables ongoing observation after fertilization and cleavage of each oocyte. The embryo quality of the ICSI and PICSI methods will be compared. | Three years |
| Measure | Description | Time Frame |
|---|---|---|
| Implantation rate | Injected sibling oocytes are incubated in a time-lapse incubator which enables ongoing observation after fertilization and cleavage of each oocyte. The implantation rates of the ICSI and PICSI methods will be compared. | Three years |
| Pregnancy rate |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Medeia Michaeli, PhD | Contact | 972-50-6246885 | medeia.michaeli@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Einat Shalom Paz, MD | Hillel Yaffe Medical Center | Principal Investigator |
| Medeia Michaeli, PhD | Hillel Yaffe Medical Center | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hillel Yaffe Medical Center | Hadera | 38100 | Israel |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| PICSI petri dish | Device | Half of the oocytes will be placed into a PICSI petri dish (whose bottom is coated with hyaluronic acid) and the mature spermatozoa with CD44 receptors that are attached to the bottom of the dish will be injected into them. |
|
Injected sibling oocytes are incubated in a time-lapse incubator which enables ongoing observation after fertilization and cleavage of each oocyte. The pregnancy rates of the ICSI and PICSI methods will be compared. |
| Three years |
| Miscarriage rate | Injected sibling oocytes are incubated in a time-lapse incubator which enables ongoing observation after fertilization and cleavage of each oocyte. The miscarriage rates of the ICSI and PICSI methods will be compared. | Three years |
| Live birth rate | Injected sibling oocytes are incubated in a time-lapse incubator which enables ongoing observation after fertilization and cleavage of each oocyte. The live birth rates of the ICSI and PICSI methods will be compared. | Three years |