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The aim of this research is to compare sibling oocytes using two sperm selection methods for choosing the best quality spermatozoa before they are injected into oocytes and the influence of each of these methods on embryo quality and IVF outcome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ICSI Procedure | Active Comparator | The ICSI procedure is the standard procedure of selection and injection of sperm into the oocyte |
|
| IMSI Procedure | Active Comparator | The IMSI procedure is the injection of normal ultramorphological spermatozoa that have been selected using an inverted microscope with magnification of 6300x (MSOME) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Standard ICSI procedure for sperm injection into oocyte | Other | The ICSI procedure is the standard procedure of selection and injection of sperm into oocytes |
|
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of fertilization rate | Injected sibling oocytes are incubated in a time-lapse incubator which enables ongoing observation after fertilization and cleavage of each oocyte. The fertilization rates of the ICSI and IMSI methods will be compared. | Three years |
| Comparison of embryo quality | Injected sibling oocytes are incubated in a time-lapse incubator which enables ongoing observation after fertilization and cleavage of each oocyte. The embryo quality of the ICSI and IMSI methods will be compared. | Three years |
| Measure | Description | Time Frame |
|---|---|---|
| Implantation rate | Injected sibling oocytes are incubated in a time-lapse incubator which enables ongoing observation after fertilization and cleavage of each oocyte. The implantation rates of the ICSI and IMSI methods will be compared. | Three years |
| Pregnancy rate |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Medeia Michaeli, PhD | Contact | 972-50-6246885 | medeia.michaeli@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Einat Shalom Paz, MD | Hillel Yaffe Medical Center | Principal Investigator |
| Medeia Michaeli, PhD | Hillel Yaffe Medical Center | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hillel Yaffe Medical Center | Hadera | 38100 | Israel |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| MSOME | Device | Selection of ultramorphologically normal spermatozoa using an inverted microscope with 6300x magnification |
|
|
| IMSI Procedure | Other | Injection of sperm that has been selected by the MSOME method into oocytes |
|
Injected sibling oocytes are incubated in a time-lapse incubator which enables ongoing observation after fertilization and cleavage of each oocyte. The pregnancy rates of the ICSI and IMSI methods will be compared. |
| Three years |
| Miscarriage rate | Injected sibling oocytes are incubated in a time-lapse incubator which enables ongoing observation after fertilization and cleavage of each oocyte. The miscarriage rates of the ICSI and IMSI methods will be compared. | Three years |
| Live birth rate | Injected sibling oocytes are incubated in a time-lapse incubator which enables ongoing observation after fertilization and cleavage of each oocyte. The live birth rates of the ICSI and IMSI methods will be compared. | Three years |