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Sponsor request
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This is an exploratory study designed to collect microbial samples from several body locations from 6 pairs of mothers and their newborn infants at various time points.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| mother infant pair | mother infant pair, singleton infant, vaginal birth |
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| Measure | Description | Time Frame |
|---|---|---|
| Maternal staphylococci is transferred to infant during and following birth. | presence of maternal staphylococci strain in infant | 6 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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pregnant mothers and their infants, planning a vaginal birth and breastfeeding as primary source of nutrition
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| Name | Affiliation | Role |
|---|---|---|
| Joseph Welter, MD | Marshfield Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Marshfield Clinic | Marshfield | Wisconsin | 54449 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19892944 | Background | Costello EK, Lauber CL, Hamady M, Fierer N, Gordon JI, Knight R. Bacterial community variation in human body habitats across space and time. Science. 2009 Dec 18;326(5960):1694-7. doi: 10.1126/science.1177486. Epub 2009 Nov 5. | |
| 18713063 | Background | Dowd SE, Sun Y, Wolcott RD, Domingo A, Carroll JA. Bacterial tag-encoded FLX amplicon pyrosequencing (bTEFAP) for microbiome studies: bacterial diversity in the ileum of newly weaned Salmonella-infected pigs. Foodborne Pathog Dis. 2008 Aug;5(4):459-72. doi: 10.1089/fpd.2008.0107. |
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staphlococci isolates
| 21697884 | Background | Capone KA, Dowd SE, Stamatas GN, Nikolovski J. Diversity of the human skin microbiome early in life. J Invest Dermatol. 2011 Oct;131(10):2026-32. doi: 10.1038/jid.2011.168. Epub 2011 Jun 23. |
| 25578246 | Background | Mueller NT, Bakacs E, Combellick J, Grigoryan Z, Dominguez-Bello MG. The infant microbiome development: mom matters. Trends Mol Med. 2015 Feb;21(2):109-17. doi: 10.1016/j.molmed.2014.12.002. Epub 2014 Dec 11. |
| 22473366 | Background | Johnson CL, Versalovic J. The human microbiome and its potential importance to pediatrics. Pediatrics. 2012 May;129(5):950-60. doi: 10.1542/peds.2011-2736. Epub 2012 Apr 2. |
| 23111681 | Background | Madan JC, Farzan SF, Hibberd PL, Karagas MR. Normal neonatal microbiome variation in relation to environmental factors, infection and allergy. Curr Opin Pediatr. 2012 Dec;24(6):753-9. doi: 10.1097/MOP.0b013e32835a1ac8. |