Immune Responses and Immunological Tolerance After Rabies Booster Vaccination in HIV-infected Adults

Humoral and Cell-mediated Immune Responses and Immunological Tolerance After Rabies Booster Vaccination in Previously Rabies Immunized HIV-infected Adults

To study the humoral and cell-mediated immune responses in HIV-infected adults who had previously received rabies booster vaccination more than a year before

Previous study has shown the higher immunogenicity response among HIV-infected adults who received a single visit 4-site intradermal rabies booster vaccination than those who received the conventional intramuscular regimen. The investigators follow the persistence of these effects. Also, the regulatory T cell levels were examined after the rabies booster vaccination .

Inclusion Criteria:

• Healthy HIV-infected adults
• Previously received rabies booster vaccination by participation in the previous clinical trials of the investigators.

Exclusion Criteria:

• Have any active opportunistic infections
• Received blood or blood product within 3 months
• Received anti-malarial drugs
• Received rabies vaccination in a previous year.