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To study the humoral and cell-mediated immune responses in HIV-infected adults who had previously received rabies booster vaccination more than a year before
Previous study has shown the higher immunogenicity response among HIV-infected adults who received a single visit 4-site intradermal rabies booster vaccination than those who received the conventional intramuscular regimen. The investigators follow the persistence of these effects. Also, the regulatory T cell levels were examined after the rabies booster vaccination .
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| single visit 4-site ID vaccination | Experimental | Blood would be drawn from those who received a single visit 4-site ID rabies booster vaccination in the previous trial. |
|
| Conventional IM vaccination | Active Comparator | Blood would be drawn from those who received a conventional intramuscular rabies booster vaccination in the previous trial. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood drawn after rabies booster vaccination | Procedure | Blood would be drawn for testing of rabies neutralizing antibody titers, rabies specific T lymphocytes and regulatory T cells after receipt of rabies booster vaccination at least a year before. |
| Measure | Description | Time Frame |
|---|---|---|
| Rabies Neutralizing Antibody Titers (RNab) | Rabies Neutralizing Antibody Titers would be represented and compared by geometric mean titers (GMTs) | GMTs of RNab and proportion of volunteers who have had RNab above protective antibody levels (0.5 IU/ml) after receipt of rabies booster vaccination at least a year before were compared between 2 arms at one time point on the date of study recruitment. |
| Measure | Description | Time Frame |
|---|---|---|
| Rabies specific T cell response | Rabies specific T cell response is measured by Enzyme - linked Immunospot Assay (ELISPOT) | Numbers of spots, of which represent the rabies specific T cell response after receipt of rabies booster vaccination at least a year before were compared between 2 arms at one time point on the date of study recruitment. |
| Measure | Description | Time Frame |
|---|---|---|
| Rabies specific regulatory T cells | Rabies specific regulatory T cells is measured by flow cytometry method | Numbers of Rabies specific regulatory T cells after receipt of rabies booster vaccination at least a year before were compared between 2 arms at one time point on the date of study recruitment. |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Suda Sibunruang, MD | Contact | +66 2 2520161 | 125 | sudapunrin@gmail.com |
| Terapong Tantawichien, MD | Contact | +66 2 2520161 | 132 | terapong_tantawichien@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Suda Sibunruang, MD | Queen Saovabha Memorial Institute | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Queen Saovabha Memorial Institute | Recruiting | Bangkok | 10330 | Thailand |
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| ID | Term |
|---|---|
| D011818 | Rabies |
| ID | Term |
|---|---|
| D018353 | Rhabdoviridae Infections |
| D018701 | Mononegavirales Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
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The volunteers who participated in the previous clinical trials were invited to join this study. Of which, there were 2 groups, one received a single visit 4-site intradermal rabies booster vaccination. The another received a conventional intramuscular rabies booster vaccination on day 0 and 3.
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| D007239 | Infections |