Immune Responses After a Four-site Intradermal Rabies Booster Vaccination in HIV-infected Adults

Humoral and Cell-mediated Immune Responses After a Four-site Intradermal Rabies Booster Vaccination in Previously Rabies Immunized HIV-infected Adults

A four-site intradermal rabies booster vaccination in HIV - infected patients who have ever received primary rabies vaccination could improve their immune response to this kind of vaccine.

A four-site intradermal rabies booster vaccination has shown higher immune response than conventional intramuscular rabies booster vaccination in healthy persons. So, the investigators hypothesized the same outcome in HIV - infected patients.

Inclusion Criteria:

• HIV infected patients
• Age 18 - 60 years
• Received primary rabies immunization

Exclusion Criteria:

• Have any active opportunistic infections
• Received blood or blood product within 3 months
• Allergy to vaccine or any vaccine components
• Received anti-malarial drugs