Immune Response After Booster Vaccination in HIV - Infected Patients Who Received Rabies Primary Vaccination

Immune Response After Booster Vaccination in HIV - Infected Patients Who Ever Received Rabies Primary Vaccination

Booster rabies vaccination in HIV - infected patients who have ever received rabies primary vaccination could improve their immune response to this kind of vaccine.

The investigators have learned from the previous studies that some HIV-infected patients especially those with low CD4+ T-lymphocyte count had poor antibody response to rabies vaccination. Because of the role of the memory B cell, the investigators hypothesized that primary rabies immunization in HIV-infected patients could rise rapid anamnestic antibody response to ones after booster vaccination in case of re-exposure of rabies occur despite of their immunocompromised state.

Inclusion Criteria:

• HIV infected patients 18-60 years of age
• Ever received primary rabies immunization

Exclusion Criteria:

• currently have any active opportunistic infections
• have received blood or blood product within previous 3 months
• history of allergy to vaccine or any vaccine components
• currently received anti-malarial drugs