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| Name | Class |
|---|---|
| University of Copenhagen | OTHER |
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To investigate the effects of different fat metabolites on gut hormone secretion in gastric bypass operated subjects and BMI-matched controls.
Dietary triglycerides are hydrolyzed during digestion to two fatty acids and one 2-monoacyl glycerol. The study will investigate the effects of these different fat components on gut hormone secretion in gastric bypass operated patients and non-operated BMI-matched controls.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 10 gastric bypass operated patients | Experimental | 3 different oils ingested at separate study days will be tested against each others ability to induce gut hormone secretion. |
|
| 10 healthy control subjects | Experimental | 3 different oils ingested at separate study days will be tested against each others ability to induce gut hormone secretion. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| C-8 dietary oil | Dietary Supplement | Ingestion of 13.15 g C-8 dietary oil providing 0.0216 mol of triglycerides. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Within group difference in glucagon-like peptide-1 (GLP-1) secretion (evaluated by AUC above basal). | Comparison of the GLP-1 responses (evaluated by AUC above basal) induced by the different oils. | 0-240 min following fat ingestion. |
| Within group difference in Gastric Inhibitory Peptide (GIP) secretion (evaluated by AUC above basal). | Comparison of the GIP responses (evaluated by AUC above basal) induced by the different oils. | 0-240 min following fat ingestion. |
| Within group difference in cholecystokinin (CCK) secretion (evaluated by AUC above basal). | Comparison of the CCK responses (evaluated by AUC above basal) induced by the different oils. | 0-240 min following fat ingestion. |
| Measure | Description | Time Frame |
|---|---|---|
| Between group comparison of GLP-1 secretion (evaluated by AUC above basal). | GLP-1 secretion (evaluated by AUC above basal) in gastric bypass operated patients compared to BMI-matched control subjects for each of the oils. | 0-240 min following fat ingestion. |
| Between group comparison of GIP secretion (evaluated by AUC above basal). |
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Gastric bypass operated patients:
Inclusion Criteria:
Exclusion Criteria:
Healthy control subjects:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sten Madsbad, Professor | Contact | +4538623032 | sten.madsbad@regionh.dk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dept. of Endocrinology | Hvidovre | 2650 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31742316 | Derived | Martinussen C, Dirksen C, Bojsen-Moller KN, Svane MS, Carlsson ER, Hartmann B, Clausen TR, Veedfald S, Kristiansen VB, Rehfeld JF, Hansen HS, Holst JJ, Madsbad S. Intestinal sensing and handling of dietary lipids in gastric bypass-operated patients and matched controls. Am J Clin Nutr. 2020 Jan 1;111(1):28-41. doi: 10.1093/ajcn/nqz272. |
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| ID | Term |
|---|---|
| D050177 | Overweight |
| D009765 | Obesity |
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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| ID | Term |
|---|---|
| C003637 | tricaprylin |
| D000069463 | Olive Oil |
| ID | Term |
|---|---|
| D004042 | Dietary Fats, Unsaturated |
| D004041 | Dietary Fats |
| D005223 | Fats |
| D008055 | Lipids |
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| Tricaprylin | Dietary Supplement | Ingestion of 10.17 g tricaprylin providing 0.0216 mol of triglycerides. |
|
| Olive oil | Dietary Supplement | Ingestion of 19 g olive oil providing 0.0216 mol of triglycerides. |
|
GIP secretion (evaluated by AUC above basal) in gastric bypass operated patients compared to BMI-matched control subjects for each of the oils. |
| 0-240 min following fat ingestion. |
| Between group comparison of CCK secretion (evaluated by AUC above basal). | GIP secretion (evaluated by AUC above basal) in gastric bypass operated patients compared to BMI-matched control subjects for each of the oils. | 0-240 min following fat ingestion. |
| Responses (evaluated by AUC above basal) of insulin within and between groups. | 0-240 min following fat ingestion. |
| Responses (evaluated by AUC above basal) of C-peptide within and between groups. | 0-240 min following fat ingestion. |
| Responses (evaluated by AUC above basal) of peptide YY (PYY) within and between groups. | 0-240 min following fat ingestion. |
| Responses (evaluated by AUC above basal) of oxyntomodulin within and between groups. | 0-240 min following fat ingestion. |
| Responses (evaluated by AUC above basal) of glucagon within and between groups. | 0-240 min following fat ingestion. |
| Responses (evaluated by AUC above basal) of bile acids within and between groups. | 0-240 min following fat ingestion. |
| Responses (evaluated by AUC above basal) of fibroblast growth factor 19 (FGF-19) within and between groups. | 0-240 min following fat ingestion. |
| Responses (evaluated by AUC above basal) of lipid metabolites (triglyceride, cholesterol, fatty acids) within and between groups. | 0-240 min following fat ingestion. |
| Responses (evaluated by AUC above basal) of neurotensin within and between groups. | 0-240 min following fat ingestion. |
| Responses (evaluated by AUC above basal) of glucose within and between groups. | 0-240 min following fat ingestion. |
| Between group comparison of differences in GLP-1 secretion (evaluated by AUC above basal). | Differences in GLP-1 secretion (evaluated by AUC above basal) induced by the different oils in gastric bypass operated patients compared with differences in BMI-matched control subjects. | 0-240 min following fat ingestion. |
| Between group comparison of differences in GIP secretion (evaluated by AUC above basal). | Differences in GIP secretion (evaluated by AUC above basal) induced by the different oils in gastric bypass operated patients compared with differences in BMI-matched control subjects. | 0-240 min following fat ingestion. |
| Between group comparison of differences in CCK secretion (evaluated by AUC above basal). | Differences in CCK secretion (evaluated by AUC above basal) induced by the different oils in gastric bypass operated patients compared with differences in BMI-matched control subjects. | 0-240 min following fat ingestion. |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D005224 |
| Fats, Unsaturated |
| D010938 | Plant Oils |
| D009821 | Oils |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |