Fat Metabolites and Gut Hormones

Effects of Fat Metabolites on Gut Hormone Secretion After Gastric Bypass Surgery

To investigate the effects of different fat metabolites on gut hormone secretion in gastric bypass operated subjects and BMI-matched controls.

Dietary triglycerides are hydrolyzed during digestion to two fatty acids and one 2-monoacyl glycerol. The study will investigate the effects of these different fat components on gut hormone secretion in gastric bypass operated patients and non-operated BMI-matched controls.

Gastric bypass operated patients:

Inclusion Criteria:

• Uncomplicated gastric bypass surgery performed minimum 12 months prior to study

Exclusion Criteria:

• Type 1 or 2 diabetes mellitus prior to or after gastric bypass surgery
• Pregnancy or breastfeeding
• Haemoglobin levels below 6,5 mM
• Gall bladder removal

Healthy control subjects:

Exclusion Criteria:

• Bariatric surgery or complicated upper abdominal surgery
• Gall bladder removal
• Pregnancy or breastfeeding
• Haemoglobin levels below 6,5 mM
• Co-morbidities or medicine significantly affecting glucose metabolism or appetite regulation