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| Name | Class |
|---|---|
| University of Copenhagen | OTHER |
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To investigate the secretion of gut hormones, in particular glucagon-like peptide 1 (GLP-1), after ingestion of glucose and fructose as separate monosaccharides or combined in the disaccharides sucrose and isomaltulose and the effect of acarbose in gastric bypass operated subjects and BMI-matched controls.
Disaccharides such as sucrose or isomaltulose (also called palatinose) require digestion into monosaccharides (both are digested to glucose and fructose) by enzymes located in the brush border of the small intestine to be absorbed. The study will investigate the influence of carbohydrate digestion on gut hormone secretion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 10 gastric bypass operated patients | Experimental | 4 different carbohydrate loads ingested at separate study days will be tested against each others ability to induce GLP-1 secretion. |
|
| 10 healthy control subjects | Experimental | 4 different carbohydrate loads ingested at separate study days will be tested against each others ability to induce GLP-1 secretion. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Glucose + Fructose | Other | Ingestion of the separate monosaccharides glucose (25 g) and fructose (25 g) dissolved in 200 mL of water. The load provides 0.1385 mol glucose and 0.1385 mol fructose. |
| Measure | Description | Time Frame |
|---|---|---|
| Within group difference in GLP-1 secretion (evaluated by iAUC). | Comparison of the GLP-1 responses (evaluated by iAUC) induced by the different carbohydrate loads. | 0-240 min following carbohydrate ingestion |
| Measure | Description | Time Frame |
|---|---|---|
| Between group comparison of GLP-1 secretion (evaluated by iAUC). | GLP-1 secretion (evaluated by iAUC) in gastric bypass operated patients compared to BMI-matched control subjects for each of the carbohydrate loads. | 0-240 min following carbohydrate ingestion |
| Between group comparison of differences in GLP-1 secretion (evaluated by iAUC). |
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Gastric bypass operated patients:
Inclusion Criteria:
Exclusion Criteria:
Healthy control subjects:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dept. of Endocrinology | Hvidovre | 2650 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30844053 | Derived | Martinussen C, Bojsen-Moller KN, Dirksen C, Svane MS, Kristiansen VB, Hartmann B, Holst JJ, Madsbad S. Augmented GLP-1 Secretion as Seen After Gastric Bypass May Be Obtained by Delaying Carbohydrate Digestion. J Clin Endocrinol Metab. 2019 Aug 1;104(8):3233-3244. doi: 10.1210/jc.2018-02661. |
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| ID | Term |
|---|---|
| D050177 | Overweight |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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| ID | Term |
|---|---|
| D005947 | Glucose |
| D005632 | Fructose |
| D013395 | Sucrose |
| C008189 | isomaltulose |
| D020909 | Acarbose |
| ID | Term |
|---|---|
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |
| D007661 |
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| Sucrose | Other | Ingestion of the disaccharide sucrose (47.5 g) dissolved in 200 mL of water. The load provides 0.1385 mol glucose and 0.1385 mol fructose. |
|
| Isomaltulose | Other | Ingestion of the slowly digestable disaccharide isomaltulose (47.5 g) dissolved in 200 mL of water. The load provides 0.1385 mol glucose and 0.1385 mol fructose. |
|
| Sucrose + Acarbose | Other | Ingestion of the disaccharide sucrose (47.5 g) and the alpha glucosidase inhibitor acarbose dissolved in 200 mL of water. The load provides 0.1385 mol glucose and 0.1385 mol fructose. |
|
Differences in GLP-1 secretion (evaluated by iAUC) induced by the different carbohydrate loads in gastric bypass operated patients compared to differences in BMI-matched control subjects. |
| 0-240 min following carbohydrate ingestion |
| Responses (evaluated by iAUC) of glucose within and between groups. | 0-240 min following carbohydrate ingestion |
| Responses (evaluated by iAUC) of insulin within and between groups. | 0-240 min following carbohydrate ingestion |
| Responses (evaluated by iAUC) of C-Peptide within and between groups. | 0-240 min following carbohydrate ingestion |
| Responses (evaluated by iAUC) of peptide YY (PYY) within and between groups. | 0-240 min following carbohydrate ingestion |
| Responses (evaluated by iAUC) of Gastric Inhibitory Peptide (GIP) within and between groups. | 0-240 min following carbohydrate ingestion |
| Responses (evaluated by iAUC) of glucagon within and between groups. | 0-240 min following carbohydrate ingestion |
| Responses (evaluated by iAUC) of oxyntomodulin within and between groups. | 0-240 min following carbohydrate ingestion |
| Responses (evaluated by iAUC) of cholecystokinin (CCK) within and between groups. | 0-240 min following carbohydrate ingestion |
| Responses (evaluated by iAUC) of bile acids within and between groups. | 0-240 min following carbohydrate ingestion |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| Ketoses |
| D004187 | Disaccharides |
| D009844 | Oligosaccharides |
| D011134 | Polysaccharides |
| D014312 | Trisaccharides |