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| Name | Class |
|---|---|
| University of Copenhagen | OTHER |
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The purpose of this study is to determine the type of macronutrient (carbohydrate, lipid or protein) that most potently stimulates the endogen secretion of different gut hormones (primary outcome = Glucagon-Like peptide-1) in gastric bypass operated patients. The study also includes a comparison of the secretion of gut hormones after oral intake of lipid with or without a pancreatic lipase inhibitor.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 10 Roux-en-Y gastric bypass patients | Isocaloric amounts of specific macronutrients is mixed with 4 g vegetable bouillon and tested against each others ability to induce GLP-1 secretion. The mealtest takes place at 4 different days with 3-14 days separation. |
| |
| 10 Healthy Control subjects | Isocaloric amounts of specific macronutrients is mixed with 4 g vegetable bouillon and tested against each others ability to induce GLP-1 secretion. The mealtest takes place at 4 different days with 3-14 days separation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mealtest: High protein 200 kcal 200 ml liquid meal consumed during 10 minutes | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Within group difference in Glucagon-like Peptide 1 secretion (evaluated by iAUC). | I.e. Comparison of GLP-1 secretion (iAUC) as a result of intake of different macronutrients between a) gastric bypass patients only b) healthy volunteers only. | Basline, 0, 15, 30, 45, 60, 90, 120, 180, 240 |
| Measure | Description | Time Frame |
|---|---|---|
| Within group difference in Glucagon secretion (evaluated by iAUC). | Basline, 0, 15, 30, 45, 60, 90, 120, 180, 240 | |
| Within group difference in Glucose-dependent insulinotropic peptide secretion (evaluated by iAUC). | Basline, 0, 15, 30, 45, 60, 90, 120, 180, 240 |
| Measure | Description | Time Frame |
|---|---|---|
| Between groups difference in Glucagon-like Peptide 1 secretion (evaluated by iAUC). | I.e. Comparison of GLP-1 secretion (iAUC) as a result of intake of different macronutrients between Gastric bypass operated patients and Healthy volunteers. | Basline, 0, 15, 30, 45, 60, 90, 120, 180, 240 |
| Between groups difference in Glucagon secretion (evaluated by iAUC). |
RYGB Patients:
Inclusion Criteria:
Exclusion Criteria:
Healthy control subjects:
Inclusion Criteria:
Exclusion Criteria:
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RYGB Patients who have underwent RYGB surgery more than 18 months earlier, weight stabile (+/- 5 kg during 1 month). Healthy control subjects who have not underwent bariatric surgery.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Endocrinology Research Center, Hvidovre University Hospital | Hvidovre | Copenhagen | 2650 | Denmark |
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Plasma and serum.
| Mealtest: High fat 200 kcal 200 ml liquid meal consumed during 10 minutes | Other |
|
|
| Mealtest: High carbohydrate 200 kcal 200 ml liquid meal consumed during 10 minutes | Other |
|
|
| Mealtest: High fat 200 kcal 200 ml liquid meal with pancreatic lipase inhibitor consumed during 10 minutes | Other |
|
|
| Within group difference in Cholecystokinin secretion (evaluated by iAUC). | Basline, 0, 15, 30, 45, 60, 90, 120, 180, 240 |
| Within group difference in Peptide YY 3-36 secretion (evaluated by iAUC). | Basline, 0, 15, 30, 45, 60, 90, 120, 180, 240 |
| Within group difference in Ghrelin secretion (evaluated by iAUC). | 0, 30, 45, 60, 120, 180, 240 |
| Within group difference in Changes in bile acids. | 0, 30, 45, 60, 120, 180, 240 |
| Within group difference in Changes in glycerol, triacylglycerol and free fatty acids. | 0, 30, 45, 60, 120, 180, 240 |
| Within group difference in Insulin secretion (evaluated by iAUC). | 2xBasline, 0, 10, 15, 20, 30, 40, 45, 60, 90, 120, 180, 240 |
| Within group difference in Plasma glucose concentration. | 2xBasline, 0, 5, 10, 15, 20, 25, 30, 40, 45, 60, 90, 120, 180, 240 |
| Within group difference in Visual Analog Scale. | Hunger, satiety, abdominal pain and nausea measured by standard 10 cm Visual Analog Scale | 0, 30, 60, 90, 120, 180, 240 |
| Within group difference in Ad libitum food intake (grams). | 240 |
| Within group difference in Heart rate (bpm). | 2xBasline, 0, 5, 10, 15, 20, 25, 30, 40, 45, 60, 90, 120, 180, 240 |
| Within group difference in Blood pressure (mmhg). | 0, 15, 30, 45, 60, 90, 120, 180, 240 |
| Basline, 0, 15, 30, 45, 60, 90, 120, 180, 240 |
| Between groups difference in Glucose-dependent insulinotropic peptide secretion (evaluated by iAUC). | Basline, 0, 15, 30, 45, 60, 90, 120, 180, 240 |
| Between groups difference in Cholecystokinin secretion (evaluated by iAUC). | Basline, 0, 15, 30, 45, 60, 90, 120, 180, 240 |
| Between groups difference in Peptide YY 3-36 secretion (evaluated by iAUC). | Basline, 0, 15, 30, 45, 60, 90, 120, 180, 240 |
| Between groups difference in Ghrelin secretion (evaluated by iAUC). | 0, 30, 45, 60, 120, 180, 240 |
| Between groups difference in Changes in bile acids. | 0, 30, 45, 60, 120, 180, 240 |
| Between groups difference in Changes in glycerol, triacylglycerol and free fatty acids. | 0, 30, 45, 60, 120, 180, 240 |
| Between groups difference in Insulin secretion (evaluated by iAUC). | 2xBasline, 0, 10, 15, 20, 30, 40, 45, 60, 90, 120, 180, 240 |
| Between groups difference in Plasma glucose concentration. | 2xBasline, 0, 5, 10, 15, 20, 25, 30, 40, 45, 60, 90, 120, 180, 240 |
| Between groups difference in Visual Analog Scale. | Hunger, satiety, abdominal pain and nausea measured by standard 10 cm Visual Analog Scale | 0, 30, 60, 90, 120, 180, 240 |
| Between groups difference in Ad libitum food intake (grams). | 240 |
| Between groups difference in Heart rate (bpm). | 2xBasline, 0, 5, 10, 15, 20, 25, 30, 40, 45, 60, 90, 120, 180, 240 |
| Between groups difference in Blood pressure (mmhg). | 0, 15, 30, 45, 60, 90, 120, 180, 240 |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D001835 | Body Weight |
| D009765 | Obesity |
| D044343 | Overnutrition |
| ID | Term |
|---|---|
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D018955 | CD36 Antigens |
| ID | Term |
|---|---|
| D010980 | Platelet Membrane Glycoproteins |
| D008562 | Membrane Glycoproteins |
| D006023 | Glycoproteins |
| D006001 | Glycoconjugates |
| D002241 | Carbohydrates |
| D050612 | Fatty Acid Transport Proteins |
| D026901 | Membrane Transport Proteins |
| D002352 | Carrier Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D008565 | Membrane Proteins |
| D011956 | Receptors, Cell Surface |
| D011971 | Receptors, Immunologic |
| D051122 | Scavenger Receptors, Class B |
| D051116 | Receptors, Scavenger |
| D011973 | Receptors, LDL |
| D018110 | Receptors, Lipoprotein |
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