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This study evaluates the clinical efficacy of the famous prescription in the treatment of unstable angina pectoris. All of the patients will be divided into 4 arms according to their syndrome type. One of the arms will be treated by conventional western medicine, the other three will be treated by different Chinese herbal medicine prescription at the base of conventional western medicine.
Xuefu Zhuyu Decoction has the function of activating qi and promoting blood circulation, which will be used to treat patients with qi stagnation and blood stasis syndrome.
GualouXiebaiBanxia Decoction compounded with Danshen Decoction has the effect of promoting blood circulation and resolving phlegm, so it will be used for patients taht belong to phlegm and blood stasis type.
Shuanghe Decoction has the function of supplementing Qi and activating blood circulation, which will be used to treat patients with Qi deficiency and blood stasis syndrome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| conventional western medicine | Other | Patients in this group will be treated by conventional western medicine, including anti-platelet drugss,lipid regulating drugs, coronary vasodilator, etc. |
|
| Qi deficiency and blood stasis | Experimental | Patients in this group will be treated by Shuanghe Decoction at the base of conventional western medicine. |
|
| Qi stagnation and blood stasis | Experimental | Patients in this group will be treated by Xuefu Zhuyu Decoction at the base of conventional western medicine. |
|
| Phlegm and blood stasis | Experimental | Patients in this group will be treated by Gualou Xiebai Banxia Decoction & Danshen Decoction at the base of conventional western medicine. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Anti-Platelet Drugs | Drug | Including aspirin and clopidogrel, etc. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mortality | Death caused by cardiovascular disease | Six months after drug intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Myocardial enzymes | The unit is mmol/L | At baseline and 4 weeks after drug intervention |
| Blood lipid | The unit is mmol/L. | At baseline and 4 weeks after drug intervention |
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Inclusion Criteria:
Patients have at least one of these symptoms:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Panpan Tian | Contact | +86 15652388175 | 15652388175@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Jun Li, MD | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23737852 | Background | Wang J, Yang X, Chu F, Chen J, He Q, Yao K, Teng F, Gao Y, Xing Y, Wu A, Xing Y. The effects of xuefu zhuyu and shengmai on the evolution of syndromes and inflammatory markers in patients with unstable angina pectoris after percutaneous coronary intervention: a randomised controlled clinical trial. Evid Based Complement Alternat Med. 2013;2013:896467. doi: 10.1155/2013/896467. Epub 2013 May 8. | |
| 23762142 |
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| ID | Term |
|---|---|
| D000789 | Angina, Unstable |
| ID | Term |
|---|---|
| D000787 | Angina Pectoris |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D057847 | Lipid Regulating Agents |
| C513826 | Xue-Fu-Zhu-Yu decoction |
| C000722533 | gualou xiebai banxia decoction |
| ID | Term |
|---|---|
| D045506 | Therapeutic Uses |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
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| Lipid Regulating Drugs | Drug | Mainly including statins |
|
| Coronary Vasodilator | Drug | Mainly including nitrates |
|
| Xuefu Zhuyu Decoction | Drug | Mainly including Peach Kernel, Safflower, Angelica, Bupleurum etc. |
|
| Gualou Xiebai Banxia Decoction & Danshen Decoction | Drug | Mainly including Fructus Trichosanthis, Rhizoma Pinelliae, Allium, Salvia Miltiorrhiza etc. |
|
| Shuanghe Decoction | Drug | Mainly including Ginseng, Poria, Calamus, Cyperus, Salvia miltiorrhiza, Radix Polygalae etc. |
|
| Treadmill exercise test | The result will be positive or negative | At baseline and 4 weeks after drug intervention |
| The incidence of myocardial infarction or heart failure | Six months after drug intervention |
| Result |
| Wang J, Yu G. A Systems Biology Approach to Characterize Biomarkers for Blood Stasis Syndrome of Unstable Angina Patients by Integrating MicroRNA and Messenger RNA Expression Profiling. Evid Based Complement Alternat Med. 2013;2013:510208. doi: 10.1155/2013/510208. Epub 2013 May 14. |
| 25254054 | Result | Yi GZ, Qiu YQ, Xiao Y, Yuan LX. The usefulness of xuefu zhuyu tang for patients with angina pectoris: a meta-analysis and systematic review. Evid Based Complement Alternat Med. 2014;2014:521602. doi: 10.1155/2014/521602. Epub 2014 Aug 31. |
| 22536282 | Result | Qiu Y, Xu H, Shi D. Traditional chinese herbal products for coronary heart disease: an overview of cochrane reviews. Evid Based Complement Alternat Med. 2012;2012:417387. doi: 10.1155/2012/417387. Epub 2012 Mar 28. |
| 27777598 | Result | Liu W, Xiong X, Yang X, Chu F, Liu H. The Effect of Chinese Herbal Medicine Gualouxiebaibanxia Decoction for the Treatment of Angina Pectoris: A Systematic Review. Evid Based Complement Alternat Med. 2016;2016:8565907. doi: 10.1155/2016/8565907. Epub 2016 Sep 29. |
| D014652 |
| Vascular Diseases |
| D002637 | Chest Pain |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |