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Compared with standardized western medical drug therapy, this study is mainly about whether the combination of standardized western medical drug therapy and Chinese medical continued treatment, can further decrease the rate of cardiovascular events for stable angina patients and change the condition of angina.
We will pick 1100 patients who are according with the II、III stage in CHD western medical diagnosis standard, treat them with combination of standardized western medical drug therapy and Chinese medical continued treatment, or only with standardized western medical drug therapy,the treat course will last 6 months. The patients will be separated in two groups: Integrative treatment of Chinese medicine and western medicine group(integrative group) and western medical group according to the exposure factors(whether the patients accept differentiation of TCM ) during the follow-up period, observe the main indexes: Primary Endpoint: all because of death, stroke, nonfatal myocardial infarction, revascularization. Secondary endpoint: the events needed hospitalization which are because of (acute coronary syndrome)ACS,heart failure, severe arrhythmia, and complications. Secondary indexes: angina symptoms. Including the attack times, lasting time, inducing factors of angina attacks, pain degree of angina, discontinue rate of nitroglycerin, and electrocardiogram.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Integrative Chinese and western medicine | Integrative Chinese and western medicine group treat with western medical therapy for CHD refering to the 'Chronic stable angina pectoris diagnosis and treatment guide'which is published by Chinese society of Cardiology, Chinese Medical Association in March, 2007, including the anti-ischemia treatment(nitric acid ester,β-blocker,calcium antagonist,ACEI), anti platelet therapy(aspirin and/or clopidogrel) and other statins.TCM should be confirmed by the physicians, according to the syndrome differentiation and the treat plan recommended in this study. | ||
| Western medicine | western medical therapy for CHD can refer to the 'Chronic stable angina pectoris diagnosis and treatment guide'which is published by Chinese society of Cardiology, Chinese Medical Association in March, 2007, including the anti-ischemia treatment(nitric acid ester,β-blocker,calcium antagonist,ACEI), anti platelet therapy(aspirin and/or clopidogrel) and other statins. |
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| Measure | Description | Time Frame |
|---|---|---|
| Primary end point all cause death | all because of death, stroke, nonfatal myocardial infarction, revascularization. | up to 12 months |
| Secondary endpoint hospitalization | the events needed hospitalization which are because of (acute coronary syndrome)ACS,heart failure, severe arrhythmia, and complications | up to 12months |
| Measure | Description | Time Frame |
|---|---|---|
| Angina symptoms | Including the attack times, lasting time, inducing factors of angina attacks, pain degree of angina, discontinue rate of nitroglycerin. | up to 12months |
| electrocardiogram | up to 12months |
| Measure | Description | Time Frame |
|---|---|---|
| safety indicators | ALT ,AST,BUN,CR,blood routine examination,urine routine | up to 12months |
Inclusion Criteria:
Exclusion Criteria:
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treat with combination of standardized western medical drug therapy and Chinese medical continued treatment
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| Name | Affiliation | Role |
|---|---|---|
| deng yue | dirctor | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jilin Province TCM Institute of Chinese Medicine | Changchun | Jilin | 130000 | China |
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| ID | Term |
|---|---|
| D000787 | Angina Pectoris |
| D003324 | Coronary Artery Disease |
| D003327 | Coronary Disease |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D002637 | Chest Pain |
| D010146 | Pain |
| D012816 | Signs and Symptoms |
| D001161 | Arteriosclerosis |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D014652 | Vascular Diseases |
| D009461 | Neurologic Manifestations |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001157 | Arterial Occlusive Diseases |
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