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| Name | Class |
|---|---|
| Guang'anmen Hospital of China Academy of Chinese Medical Sciences | OTHER |
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This study evaluates the clinical efficacy of Xuefu Zhuyu Decoction in the treatment of unstable angina pectoris. All of the patients will be divided into 2 arms randomly. One of the arms will be treated by conventional western medicine, the other one will be treated by Xuefu Zhuyu Decoction at the base of conventional western medicine.
Xuefu Zhuyu Decoction has the function of activating qi and promoting blood circulation, which will be used to treat patients with qi stagnation and blood stasis syndrome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Qi stagnation and blood stasis | Experimental | Patients in this group will be treated by Xuefu Zhuyu Decoction at the base of conventional western medicine. |
|
| Conventional western medicine | Other | Patients in this group will be treated by conventional western medicine, including anti-platelet drugss,lipid regulating drugs, coronary vasodilator, etc. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Anti-Platelet Drugs | Drug | Including aspirin and clopidogrel, etc. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mortality | Death caused by cardiovascular disease | Six months after drug intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Myocardial enzymes | The unit is mmol/L | At baseline and 4 weeks after drug intervention |
| 3. Blood lipid The unit is mmol/L. Blood lipid | 3. Blood lipid The unit is mmol/L. 3. Blood lipid The unit is mmol/L. The unit is mmol/L |
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Inclusion Criteria:
Patients have at least one of these symptoms:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Panpan Tian | Contact | +86 15652388175 | 15652388175@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Jun Li, MD | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25254054 | Result | Yi GZ, Qiu YQ, Xiao Y, Yuan LX. The usefulness of xuefu zhuyu tang for patients with angina pectoris: a meta-analysis and systematic review. Evid Based Complement Alternat Med. 2014;2014:521602. doi: 10.1155/2014/521602. Epub 2014 Aug 31. | |
| 22536282 | Result | Qiu Y, Xu H, Shi D. Traditional chinese herbal products for coronary heart disease: an overview of cochrane reviews. Evid Based Complement Alternat Med. 2012;2012:417387. doi: 10.1155/2012/417387. Epub 2012 Mar 28. |
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| ID | Term |
|---|---|
| D000789 | Angina, Unstable |
| ID | Term |
|---|---|
| D000787 | Angina Pectoris |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D057847 | Lipid Regulating Agents |
| C513826 | Xue-Fu-Zhu-Yu decoction |
| ID | Term |
|---|---|
| D045506 | Therapeutic Uses |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
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| Lipid Regulating Drugs | Drug | Mainly including statins |
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| Coronary Vasodilator | Drug | Mainly including nitrates |
|
| Xuefu Zhuyu Decoction | Drug | Mainly including Peach Kernel, Safflower, Angelica, Bupleurum etc. |
|
| At baseline and 4 weeks after drug intervention |
| Treadmill exercise test | The result will be positive or negative | At baseline and 4 weeks after drug intervention |
| The incidence of myocardial infarction or heart failure | Six months after drug intervention |
| 27777598 | Result | Liu W, Xiong X, Yang X, Chu F, Liu H. The Effect of Chinese Herbal Medicine Gualouxiebaibanxia Decoction for the Treatment of Angina Pectoris: A Systematic Review. Evid Based Complement Alternat Med. 2016;2016:8565907. doi: 10.1155/2016/8565907. Epub 2016 Sep 29. |
| 23737852 | Result | Wang J, Yang X, Chu F, Chen J, He Q, Yao K, Teng F, Gao Y, Xing Y, Wu A, Xing Y. The effects of xuefu zhuyu and shengmai on the evolution of syndromes and inflammatory markers in patients with unstable angina pectoris after percutaneous coronary intervention: a randomised controlled clinical trial. Evid Based Complement Alternat Med. 2013;2013:896467. doi: 10.1155/2013/896467. Epub 2013 May 8. |
| 23762142 | Result | Wang J, Yu G. A Systems Biology Approach to Characterize Biomarkers for Blood Stasis Syndrome of Unstable Angina Patients by Integrating MicroRNA and Messenger RNA Expression Profiling. Evid Based Complement Alternat Med. 2013;2013:510208. doi: 10.1155/2013/510208. Epub 2013 May 14. |
| D014652 |
| Vascular Diseases |
| D002637 | Chest Pain |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |