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| Name | Class |
|---|---|
| Arla Foods | INDUSTRY |
| Team Denmark | OTHER |
| Innovation Fund Denmark | INDIV |
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A randomized interventions study using a crossover design. Ten well trained triathletes or bikeriders will be included for to undergo two trail separated by about 3 weeks. The night before the trail each subject will performe a high intense interval trainings session on an ergometer bike. during the night an infusion of aminoacid tracers will be initiated. The subject is woken at 6.30 a.m. Blood samples and a musclebiopsy will be collected prior to the morning bike ride at 8.00a.m. Immediately before the morning bike ride is started the subject will ingest a drink of 0,5g protein or a non-caloric placebo (random order). During the bike ride and the following 4,5 hours blood will be drawn with regular intervals. at time point 0, 60 and 180 min after the training session biopsies are collected.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Protein ingestion | Experimental | Subjects ingested protein drinks |
|
| Placebo | Placebo Comparator | Subjects ingested a non-caloric placebo drink |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Protein ingestion | Other | A protein drink was ingested prior to the 90min bike ride in one of the completed trails (order randomised). |
|
| Measure | Description | Time Frame |
|---|---|---|
| Muscle protein fractional synthetic rate (FSR) | FSR was measure over at time period of six hours |
| Measure | Description | Time Frame |
|---|---|---|
| Tracer kinetics dilution model | A-V tracer dilution model was applied across the forearm. | six hours |
| Muscle signalling | Muscle signalling will be determined using western blotting in each muscle biopsy |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31992300 | Derived | Larsen MS, Holm L, Svart MV, Hjelholt AJ, Bengtsen MB, Dollerup OL, Dalgaard LB, Vendelbo MH, van Hall G, Moller N, Mikkelsen UR, Hansen M. Effects of protein intake prior to carbohydrate-restricted endurance exercise: a randomized crossover trial. J Int Soc Sports Nutr. 2020 Jan 28;17(1):7. doi: 10.1186/s12970-020-0338-z. |
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Masking was done by providing similar tasting drinks at both trails. One was placebo, one was protein a drink
| Non-caloric placebo ingestion | Other | A placebo drink was ingested prior to the 90min bike ride in one of the completed trails (order randomised). |
|
| Determined in biopsies sampled before and immediatly after 90min exercise in addition to one and four hours after exercise. |
| Nitrogen excretion | nitrogen excretion is determined by Plasma and urinary carbide analysis as well as plasma NH4+. | Urine is collected during two periods. Collection period one: 12 hours prior to morning exercise. Collection period 2: During and four hours following exercise. Blood samples is drawn repeatedly from before to four hours after exercise. |