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The aim of the study is to investigate a pre and post workout supplementation (15 days) with Recoverben® , a Aloysia citriodora extract on recovery after exhaustive exercise. Effects will be investigated with 400mg Recoverben® and compared to placebo.
The aim of the study is to investigate a pre and post workout supplementation (15 days) with Recoverben® , a Aloysia citriodora extract on recovery after exhaustive exercise. Effects will be investigated with 400mg Recoverben® and compared to placebo.
Targeted parameter will be determined at the beginning of the study and after supplementation, each. Parameter include maximal strength (MVC), muscle soreness (VAS), pain sensitivity (Algometry) and biomarkers (CK, IL-6, glutathione peroxidase).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Aloysia citriodora extract | Active Comparator | Dietary Supplement: Aloysia citriodora extract |
|
| Placebo Formulation | Placebo Comparator | Dietary Supplement: Maltodextrin (no active ingredient) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aloysia citriodora extract | Dietary Supplement | 2 capsules with 200mg - daily dosage 400mg |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of muscle soreness (VAS) over time | In the current study, pain following eccentric exercise will be assessed by using a 100 mm visual analogue scale after the subjects performing a standardized movement. | Chance over time after 10 days of supplementation (pre stress test and 3h, 24h, 48 h, 96h after stress test) |
| Measure | Description | Time Frame |
|---|---|---|
| Monitoring of related adverse events | Reporting of adverse effects to evaluate tolerability | During study execution over 15 days |
| Change of maximal concentric strength/ maximal voluntary contraction (MVC) over time |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Claudia Reule, Dr. | BioTeSys GmbH | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Biotesys GmbH | Esslingen am Neckar | 73728 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29410606 | Derived | Buchwald-Werner S, Naka I, Wilhelm M, Schutz E, Schoen C, Reule C. Effects of lemon verbena extract (Recoverben(R)) supplementation on muscle strength and recovery after exhaustive exercise: a randomized, placebo-controlled trial. J Int Soc Sports Nutr. 2018 Jan 23;15:5. doi: 10.1186/s12970-018-0208-0. eCollection 2018. |
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| ID | Term |
|---|---|
| D063806 | Myalgia |
| ID | Term |
|---|---|
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D009468 | Neuromuscular Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| C008315 | maltodextrin |
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| Maltodextrin | Dietary Supplement | 2 capsules with 200mg - daily dosage 400mg |
|
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Maximal concentric strength of the M. Quadriceps femoris will be assessed by measuring maximal isometric concentric strength using a dynamometer
| Chance over time after 10 days of supplementation (pre stress test and 3h, 24h and 48 h after stress test) |
| Change of pressure pain (Algometry) over time | The threshold for pressure induced pain will be measured using an algometer. | Chance over time after 10 days of supplementation (pre stress test and 3h, 24h and 48 h after stress test) |
| Change of retrospective pain (Likert scale) over time | Evaluation of the perceived pain retrospectively by using the Likert scale for muscle soreness | Chance over time after 10 days of supplementation (pre stress test and 24h, 48h, 96h after stress test) |
| Change of creatine kinase over time | Chance over time after 10 days of supplementation (pre stress test and 3h, 24h and 48 h after stress test) |
| Change of of glutathione peroxidase over time | Chance over time after 10 days of supplementation (pre stress test and 24h and 48 h after stress test) |
| Change of interleukin-6 over time | Chance over time after 10 days of supplementation (pre stress test and 3h, 24h and 48 h after stress test) |
| D059352 | Musculoskeletal Pain |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |