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| Name | Class |
|---|---|
| European University of Madrid | OTHER |
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The study will assess the recovery and performance of young athletes suffering from muscle damage induced by physical exercise. Model by comparing the safety and efficacy of ReWin(d) supplemention during 4 weeks to placebo over 72 hours post exercice.
Double-blind, randomized, placebo controlled, parallel group, pilot safety and efficacy study.
40 healthy young male athetes were randomly assigned to the ReWin(d) or Placebo group. After 4 weeks supplementation (either 2 g daily of ReWin(d) capsules or placebo capsules). the participants were subjected to a 1 hour plyometric exercise session to induce DOMS. At 0 hours, 24 hours, 48 hours and 72 hours post exercise, the volunteers have been assessed to determine: (i) pain perception, (ii) fatigue rate, (iii) sport performance (effectiveness of a jump) and (iv) muscle damage and inflammation by I-R thermography and biomarkers
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ReWin(d) | Active Comparator | Subjects have to take ReWin(d) capsules (3 times a day, total 2 g/day) during breakfast, lunch and diner, during 4 weeks + 3 days after acute exercice |
|
| placebo | Placebo Comparator | Subjects have to take Placebo capsules (3 times a day, total 2 g/day) during breakfast, lunch and diner, during 4 weeks + 3 days after acute exercice |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Polyherbal supplement: ReWin(d) vs Placebo | Dietary Supplement | Supplementation during 4 weeks + 72 hours post acute exercice |
|
| Measure | Description | Time Frame |
|---|---|---|
| Effects of ReWin(d) on muscle recovery induced by physical exercise | Sport performance (effectiveness of a jump) after exercise-induced muscle damage | Change from baseline at 0 hours, 24 hours, 48 hours and 72 hours post plyometric exercises session to induce DOMS |
| Measure | Description | Time Frame |
|---|---|---|
| Effects of ReWin(d) on muscle damage induced by physical exercise | Muscle skin temperature monitored by IR-camera. | Change from baseline at 0 hours, 24 hours, 48 hours and 72 hours post plyometric exercises session to induce DOMS |
| Effects of ReWin(d) on pain perception induced by physical exercise |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Margarita Perez Ruiz, MD(Res) | European University of Madrid | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| European University of Madrid | Villaviciosa de Odón | Madrid | 28670 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32848820 | Derived | Dominguez-Balmaseda D, Diez-Vega I, Larrosa M, San Juan AF, Issaly N, Moreno-Perez D, Burgos S, Sillero-Quintana M, Gonzalez C, Bas A, Roller M, Perez-Ruiz M. Effect of a Blend of Zingiber officinale Roscoe and Bixa orellana L. Herbal Supplement on the Recovery of Delayed-Onset Muscle Soreness Induced by Unaccustomed Eccentric Resistance Training: A Randomized, Triple-Blind, Placebo-Controlled Trial. Front Physiol. 2020 Jul 21;11:826. doi: 10.3389/fphys.2020.00826. eCollection 2020. |
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| ID | Term |
|---|---|
| D063806 | Myalgia |
| D010146 | Pain |
| ID | Term |
|---|---|
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D009468 | Neuromuscular Diseases |
| D009422 | Nervous System Diseases |
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Single dose, Randomized, Double Blinded, Placebo-controlled Study
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Visual Analogue Scale pain perception after exercise-induced muscle damage |
| Change from baseline at 0 hours, 24 hours, 48 hours and 72 hours post plyometric exercises session |
| Effects of ReWin(d) on fatigue rate induced by physical exercise | Heart Rate Variability assessment after exercise-induced muscle damage | Change from baseline at 0 hours, 24 hours, 48 hours and 72 hours post plyometric exercises session |
| Effects of ReWin(d) on Gut Microbiota | Determination of Microbiota composition by 16S rRNA Sequencing. | Change from baseline dose after 4 weeks of intervention |
| D059352 | Musculoskeletal Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |