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| Name | Class |
|---|---|
| Ganzhou City People's Hospital | OTHER |
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The investigators will perform integrative analysis of CRC liver metastasis
The investigators will analyzed proteomes of paired normal colorectal tissues and colorectal cancer (CRC) with or without liver metastasis, sequenced transcriptomes, performed whole exome sequencing, and single nucleotide polymorphism (SNP) array profiling for triplets, each comprising normal colorectal tissue, primary colorectal carcinoma, and its synchronous matched liver metastasis, as well as analyzed genomics of CRC characterized previously by The Cancer Genome Atlas (TCGA) to conduct integrated proteogenomic analyses.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| normal colorectal tissues (PN) | normal colorectal tissues |
| |
| primary colorectal carcinoma tissues | primary colorectal carcinoma tissues |
| |
| liver metastasis tissues | liver metastasis tissues |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| normal colorectal tissues | Other | The investigators will extract total protein, DNA and RNA from these groups. |
|
| Measure | Description | Time Frame |
|---|---|---|
| 5 years overall survival | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| 5 years disease-free survival | 5 years |
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Inclusion Criteria:
Exclusion Criteria:
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patients with CRC
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Da Fu, Ph.D. | Contact | 021-66301604 | shsyiec@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Da Fu, Ph.D. | the Shanghai Tenth People's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ganzhou City People's Hospital | Recruiting | Ganzhou | Jiangxi | 341000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25651787 | Result | Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015 Mar;65(2):87-108. doi: 10.3322/caac.21262. Epub 2015 Feb 4. | |
| 30241526 | Derived | Ma YS, Huang T, Zhong XM, Zhang HW, Cong XL, Xu H, Lu GX, Yu F, Xue SB, Lv ZW, Fu D. Proteogenomic characterization and comprehensive integrative genomic analysis of human colorectal cancer liver metastasis. Mol Cancer. 2018 Sep 21;17(1):139. doi: 10.1186/s12943-018-0890-1. |
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The investigators are willing to share data.
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| ID | Term |
|---|---|
| D009362 | Neoplasm Metastasis |
| ID | Term |
|---|---|
| D009385 | Neoplastic Processes |
| D009369 | Neoplasms |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Shanghai Tenth People's Hospital | Recruiting | Shanghai | Shanghai Municipality | 200072 | China |
|