Integrative Analysis of CRC Liver Metastasis

Integrative Analysis of CRC Liver Metastasis

The investigators will perform integrative analysis of CRC liver metastasis

The investigators will analyzed proteomes of paired normal colorectal tissues and colorectal cancer (CRC) with or without liver metastasis, sequenced transcriptomes, performed whole exome sequencing, and single nucleotide polymorphism (SNP) array profiling for triplets, each comprising normal colorectal tissue, primary colorectal carcinoma, and its synchronous matched liver metastasis, as well as analyzed genomics of CRC characterized previously by The Cancer Genome Atlas (TCGA) to conduct integrated proteogenomic analyses.

Inclusion Criteria:

• Age ≤ 75 years with histologically proven CRC
• No severe major organ dysfunction
• WHO performance status of 0 or 1
• No prior cancer chemotherapy

Exclusion Criteria:

• Age ≥ 76
• Severe major organ dysfunction
• World Health Organization (WHO) performance status of >1
• Prior cancer chemotherapy