The goal of this observational study is to develop an integrated clinical-molecular risk stratification to identifypatients who are at high risk of recurrence and who would benefit from adjuvant chemotherapy in patients with recectable colorectal liver metastases. The main question it aims to answer is: can the integration of multi-dimensional data-including ctDNA, driver gene profiles, and clinical factors-accurately identify postoperative patients at high risk of recurrence and guide personalized adjuvant therapy strategies?

Inclusion Criteria:

1. Aged 18 to 75 years, inclusive (male or female).
2. Pathologically and radiologically confirmed colorectal cancer with liver metastases.
3. Must have undergone complete (R0) surgical resection of both the primary colorectal tumor and all liver metastases.
4. Have adequate organ function and no contraindications to potential adjuvant therapies (surgery, chemotherapy, radiotherapy, immunotherapy).
5. Willing and able to comply with the study protocol and follow-up visits.
6. Availability of sufficient liver metastasis tumor tissue for gene sequencing.
7. Provision of a blood sample for circulating tumor DNA (ctDNA) detection within one month after surgery but before starting any adjuvant therapy.

Exclusion Criteria:

1. Pregnancy or breast-feeding women
2. History of other malignancies within 5 years (except cured skin cancer and cervicalcancer in situ)
3. History of uncontrolled epilepsy, central nervous system disease, or psychiatricdisorders
4. Clinically serious heart disease, such as symptomatic coronary artery disease, NewYork Heart Association (NYHA) class II or worse congestive heart failure or severearrhythmia requiring pharmacologic intervention, or history of myocardial infarctionwithin the last 12 months
5. Baseline blood and biochemical indicator do not meet the following criteria:neutrophils >=1.5×10^9/L, Hb >=90g/L, PLT >=100×10^9/L, ALT/AST<=2.5 ULN, Cr <= 1ULN
6. Allergic to any component of the therapy
7. Severe uncontrolled recurrent infections

Patients were diagnosed with resectable colorectal liver metastases

The ownership and usage rights of the data from this study are subject to agreements with the participating institutions, funding organizations, and sample providers. These agreements stipulate that the data may only be used for the specific purposes of this project and, therefore, cannot be publicly shared.