Precision Medicine for Colorectal Cancer Liver Metastasis Guided by Multi-omics Data Under the Umbrella Theory

Precision Medicine for Colorectal Cancer Liver Metastasis Guided by Multi-omics Data Under the Umbrella Theory

In order to more accurately discover the cause of drug resistance in tumor treatment, and to provide a new basis for precise treatment.

Therefore, based on the umbrella theory of precision medicine, we carried out this single-center, prospective, and observational study to include patients with liver metastases from colorectal cancer. By combining genome, transcriptome, and proteomic sequencing data, we established a basis for colorectal cancer liver Transfer the multi-omics data of the sample, describe the reason for the resistance of the first-line treatment, and search for new therapeutic targets.

Inclusion Criteria:

• ECOG score 0-2 points
• Pathologically diagnosed patients with colorectal cancer
• Combined with liver metastases confirmed by imaging, and the lesion is measurable (RECIST standard)
• The lesion is available
• First-line treatment failed; hematology, liver and kidney function tests are suitable for back-line treatment
• Informed consent

Exclusion Criteria:

• With brain metastases
• History of other malignancies
• Pregnancy or breastfeeding
• Have received other drug clinical studies within 30 days before the start of this study