Correlation and Heterogeneity of the Immune Microenvironment and Histopathological Growth Patterns in Resectable Colorectal Cancer Liver Metastases

Correlation and Heterogeneity of the Immune Microenvironment and Histopathological Growth Patterns in Resectable Colorectal Cancer Liver Metastases

Correlation and Heterogeneity of the Immune Microenvironment and Histopathological Growth Patterns in Resectable Colorectal Cancer Liver Metastases

This study aims to retrospectively analyze the status and spatial heterogeneity of the tumor microenvironment (TME) in liver metastases from patients with CRLM, as well as the association between HGPs at the tumor-liver interface and postoperative recurrence following resection of liver metastases. Furthermore, this study seeks to explore the underlying mechanisms through which HGPs influence patient prognosis.

Inclusion Criteria:

• Patients with CRLM who underwent R0 resection
• Histologically or cytologically confirmed CRLM
• Have sufficient liver metastasis tissue specimens available for analysis
• Complete treatment and follow-up records

Exclusion Criteria:

• Patients did not undergo R0 resection
• Postoperative specimens were unavailable
• Clinical data were incomplete.