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| Name | Class |
|---|---|
| Shanghai Pulmonary Hospital, Shanghai, China | OTHER |
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Integrative analysis of LCLC
The investigators will analyzed proteomes of paired normal lung tissues and LCLC with or without liver metastasis, sequenced transcriptomes, perform whole exome sequencing, and single nucleotide polymorphism (SNP) array profiling for triplets, each comprising normal lung tissue, primary LCLC carcinoma, and its synchronous matched metastasis, as well as analyzed genomics of lung cancer characterized previously by The Cancer Genome Atlas (TCGA) to conduct integrated proteogenomic analyses.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal lung tissue | Normal lung tissue from LCLC patients |
| |
| LCLC tissues | LCLC tissues from LCLC patients |
| |
| Metastasis tissues | Metastasis tissues from LCLC patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Normal lung tissue | Other | The investigators will extract total protein, DNA and RNA from LCLC patients. |
|
| Measure | Description | Time Frame |
|---|---|---|
| 5 years overall survival | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| 5 years disease-free survival | 5 years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with large-cell lung cancer
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Da Fu, PhD | Contact | 00-86-21-66301604 | fu800da900@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Da Fu, PhD | Shanghai 10th People's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ganzhou City People's Hospital | Recruiting | Ganzhou | Jiangxi | 341000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25651787 | Result | Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015 Mar;65(2):87-108. doi: 10.3322/caac.21262. Epub 2015 Feb 4. |
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The investigators are willing to share data.
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| ID | Term |
|---|---|
| D008175 | Lung Neoplasms |
| D009362 | Neoplasm Metastasis |
| ID | Term |
|---|---|
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| Shanghai Tenth People's Hospital | Recruiting | Shanghai | Shanghai Municipality | 200072 | China |
|
| Shanghai Pulmonary Hospital | Recruiting | Shanghai | Shanghai Municipality | 200433 | China |
|
| D008171 |
| Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D009385 | Neoplastic Processes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |