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The objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI before and after bariatric surgery. Administration of glucose as well as fructose is followed by functional brain MRI, and findings are correlated with serum glucagon-like peptide 1 (GLP-1) levels as an endogenous satiety signal in obese humans.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PLACEBO | Placebo Comparator | Single intragastric instillation of 300ml tap water via nasogastric tube |
|
| GLUCOSE | Active Comparator | Single intragastric instillation of 75g Glucose in 300ml tap water via nasogastric tube |
|
| FRUCTOSE | Active Comparator | Single intragastric instillation of 25g Fructose in 300ml tap water via nasogastric tube |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tap water | Dietary Supplement | 300ml tap water via nasogastric tube |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Functional magnetic resonance imaging (fMRI) in healthy, obese volunteers while they performed a working memory task: changes in cerebral blood flow | changes from baseline to one hour after treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in plasma glucose | Changes from baseline to one hour after treatment | |
| Changes in plasma insulin | Changes from baseline to one hour after treatment | |
| Changes in Plasma GLP-1 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Christoph Beglinger, Prof | University of Basel | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Basel | Basel | Switzerland |
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| ID | Term |
|---|---|
| D005106 | Exploratory Behavior |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D005947 | Glucose |
| D005632 | Fructose |
| ID | Term |
|---|---|
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |
| D007661 |
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| Glucose |
| Dietary Supplement |
300ml tap water with 75g glucose via nasogastric tube |
|
| Fructose | Dietary Supplement | 300ml tap water with 25g fructose via nasogastric tube |
|
| Changes from baseline to one hour after treatment |
| Ketoses |