Glucose and Fructose Stimulated Brain Activity in Obese Subjects Before and After Bariatric Surgery

Glucose and Fructose Stimulated Brain Activity in Obese Subjects Before and After Bariatric Surgery

The objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI before and after bariatric surgery. Administration of glucose as well as fructose is followed by functional brain MRI, and findings are correlated with serum glucagon-like peptide 1 (GLP-1) levels as an endogenous satiety signal in obese humans.

Inclusion Criteria:

• right-handed
• morbidly obese patients
• scheduled for bariatric surgery

Exclusion Criteria:

• Diabetes mellitus
• cardiovascular disease
• neurologic or psychiatric disorder