Cerebral Blood Flow Changes in People With Obesity After Glucose Consumption

Cerebral Perfusion Changes in Obese Subjects After Administration of 75 Grams of Glucose. A SPECT, Controlled, Blinded and Randomized Study.

This study evaluates the hypothesis that a meal constituted of only glucose produces differences in the brain blood flow in people with obesity that are not observed in people without obesity. These changes, at least in part, could explain the mechanisms involved in maintenance or development of obesity.

Inclusion Criteria:

• Live in Ribeirão Preto, São Paulo - Brazil.
• Age between 18 and 40 years old.
• Female gender.
• Regular menses.
• Weight inferior than 120 Kg and body mass index (BMI) between 30 and 40 kg/m2, for the group with obesity.
• BMI between 18,5 and 24,9 kg/m2, for the group without obesity.

Exclusion Criteria:

• High blood pressure, diabetes, glucose intolerance or impaired fasting glycemia, metabolic syndrome, hypothyroidism and any kidney, liver, heart or neurologic disease.
• Psychiatric disorders, alcoholism, smoking or illicit drug abuse.
• Pregnancy or desire to be pregnant
• Use of medications, excluding contraceptives.
• Contraindication for magnetic resonance imaging.
• Be in treatment for obesity.