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Our objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI. Administration of glucose with and without lactisole and exendin as well as fructose is followed by functional brain MRI, and findings are correlated with serum GLP-1 levels as an endogenous satiety signal in humans.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 300ml tap water | Placebo Comparator | Single intragastric instillation of 300ml tap water via nasogastric tube |
|
| Glucose | Active Comparator | Single intragastric instillation of 75g Glucose in 300ml tap water via nasogastric tube |
|
| Glucose plus Lactisole | Active Comparator | Single intragastric instillation of 75g Glucose in 300ml tap water with 450ppm lactisole |
|
| Fructose | Active Comparator | Single intragastric instillation of 25g Fructose in 300ml tap water via nasogastric tube |
|
| Glucose and Exendin | Active Comparator | Single intragastric instillation of 75g glucose in 300ml tap water with 600pmol/kg/min exendin 9-39 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tap water | Dietary Supplement |
| ||
| Single intragastric instillation of 75g Glucose in 300ml tap water via nasogastric tube |
| Measure | Description | Time Frame |
|---|---|---|
| Functional magnetic resonance imaging (fMRI) in healthy volunteers while they performed a working memory task: changes in cerebral blood flow and blood hormones from baseline to treatment | Whole brain analysis with a cluster-level threshold was followed by an a priori defined region of interest analysis of the dorsolateral prefrontal cortex including a cluster-level threshold and family-wise error adjustment for multiple comparisons. | changes from baseline to one hour after treatment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Christoph Beglinger, MD | University Hospital, Basel, Switzerland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital | Basel | CH-4031 | Switzerland |
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| tap water, lactisole | Sham Comparator | Single intragastric instillation of 300ml tap water with 450ppm lactisole |
|
| Dietary Supplement |
|
| Single intragastric instillation of 75g Glucose in 300ml tap water with 450ppm lactisole | Dietary Supplement |
|
| 25g Fructose in 300ml tap water | Dietary Supplement |
|
| 75g glucose in 300ml tap water with 600pmol/kg/min exendin 9-39 | Dietary Supplement |
|
| 300ml tap water with 450ppm lactisole | Dietary Supplement |
|
| ID | Term |
|---|---|
| D005106 | Exploratory Behavior |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D005947 | Glucose |
| D005632 | Fructose |
| ID | Term |
|---|---|
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |
| D007661 | Ketoses |
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