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With this study the investigators investigate the effects of amino acids (tryptophan, leucin) and sugar alcohols (xylitol, erythritol) on satiety mechanisms and brain activation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1.56 g L-Tryptophan | Active Comparator | 1.56 g L-Tryptophan in 300 mL tap water given via nasogastric tube + after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube |
|
| 1.56 g L-Leucine | Active Comparator | 1.56 g L-Leucine in 300 mL tap water given via nasogastric tube + after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube |
|
| 50 g Xylitol | Active Comparator | 50 g Xylitol in 300 mL tap water given via nasogastric tube |
|
| 75 g Erythritol | Active Comparator | 75 g Erythritol in 300 mL tap water given via nasogastric tube |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 1.56 g L-Tryptophan | Dietary Supplement |
| ||
| 1.56 g L-Leucine |
| Measure | Description | Time Frame |
|---|---|---|
| Effect of aminoacids on cerebral blood flow measured by functional brain MRI | changes from baseline to one hour after treatment | |
| Effect of sugar alcohols on cerebral blood flow measured by functional brain MRI | changes from baseline to one hour after treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of Plasma Glucose concentrations | changes from baseline to three hours after treatment | |
| Measurement of Plasma Insulin concentrations | changes from baseline to three hours after treatment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Christoph Beglinger, Prof. | University Hospital, Basel, Switzerland | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Basel | Basel | Canton of Basel-City | 4031 | Switzerland |
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| 75 g Glucose and mixed liquid meal | Placebo Comparator | 75 g Glucose in 300 mL tap water given via nasogastric tube + after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube |
|
| Tap water and mixed liquid meal | Placebo Comparator | 300 mL tap water given via nasogastric tube + after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube |
|
| Dietary Supplement |
|
| 50 g Xylitol | Dietary Supplement |
|
| 75 g Erythritol | Dietary Supplement |
|
| 75 g Glucose | Dietary Supplement |
|
| Tap water | Dietary Supplement |
|
| Mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) | Dietary Supplement |
|
| Nasogastric Tube | Device |
|
| Measurement of Plasma cholecystokinin concentrations | changes from baseline to three hours after treatment |
| Measurement of Plasma Glucagon-like Peptide (GLP-1) concentrations | changes from baseline to three hours after treatment |
| Measurement of Plasma PYY concentrations | changes from baseline to three hours after treatment |
| Measurement of Plasma ghrelin concentrations | changes from baseline to three hours after treatment |
| ID | Term |
|---|---|
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D014364 | Tryptophan |
| D007930 | Leucine |
| D014993 | Xylitol |
| D004896 | Erythritol |
| D005947 | Glucose |
| D011506 | Proteins |
| D018955 | CD36 Antigens |
| D002241 | Carbohydrates |
| D004750 | Enteral Nutrition |
| ID | Term |
|---|---|
| D024322 | Amino Acids, Aromatic |
| D000598 | Amino Acids, Cyclic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D000601 | Amino Acids, Essential |
| D000597 | Amino Acids, Branched-Chain |
| D013402 | Sugar Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D010980 | Platelet Membrane Glycoproteins |
| D008562 | Membrane Glycoproteins |
| D006023 | Glycoproteins |
| D006001 | Glycoconjugates |
| D050612 | Fatty Acid Transport Proteins |
| D026901 | Membrane Transport Proteins |
| D002352 | Carrier Proteins |
| D008565 | Membrane Proteins |
| D011956 | Receptors, Cell Surface |
| D011971 | Receptors, Immunologic |
| D051122 | Scavenger Receptors, Class B |
| D051116 | Receptors, Scavenger |
| D011973 | Receptors, LDL |
| D018110 | Receptors, Lipoprotein |
| D005248 | Feeding Methods |
| D013812 | Therapeutics |
| D018529 | Nutritional Support |
| D044623 | Nutrition Therapy |
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