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With this study the investigators investigate the effects of amino acids (tryptophan in two different concentrations, leucin) and sugar alcohols (xylitol, erythritol) on satiety mechanisms.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 0.52 g L-Tryptophan | Active Comparator | 0.52 g L-Tryptophan in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube |
|
| 1.56 g L-Tryptophan | Active Comparator | 1.56 g L-Tryptophan in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube |
|
| 1.56 g L-Leucine | Active Comparator | 1.56 g L-Leucine in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube |
|
| 50 g Xylitol | Active Comparator | 50 g Xylitol in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube |
|
| 75 g Erythritol | Active Comparator | 75 g Erythritol in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 0.52 g L-Tryptophan | Dietary Supplement |
| ||
| 1.56 g L-Tryptophan |
| Measure | Description | Time Frame |
|---|---|---|
| Effect of different aminoacids and sugar alcohols on secretion of satiation hormones | Plasma concentrations of glucose | changes from baseline to three hours after treatment |
| Effect of different aminoacids and sugar alcohols on secretion of satiation hormones | Plasma concentrations of insulin are measured | changes from baseline to three hours after treatment |
| Effect of different aminoacids and sugar alcohols on secretion of satiation hormones | Plasma concentrations of glucagon are measured | changes from baseline to three hours after treatment |
| Effect of different aminoacids and sugar alcohols on secretion of satiation hormones | Plasma concentrations of glucagon-like Peptide (GLP-1) are measured | changes from baseline to three hours after treatment |
| Effect of different aminoacids and sugar alcohols on secretion of satiation hormones | Plasma concentrations of PYY are measured | changes from baseline to three hours after treatment |
| Effect of different aminoacids and sugar alcohols on secretion of satiation hormones | Plasma concentrations of cholecystokinin are measured | changes from baseline to three hours after treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Effect of different aminoacids and sugar alcohols on gastric emptying | measured by C13 breath test | changes from baseline to four hours after treatment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Christoph Beglinger, Prof. | University Hospital, Basel, Switzerland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Basel, Phase 1 Research Unit | Basel | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27875537 | Derived | Meyer-Gerspach AC, Hafliger S, Meili J, Doody A, Rehfeld JF, Drewe J, Beglinger C, Wolnerhanssen B. Effect of L-Tryptophan and L-Leucine on Gut Hormone Secretion, Appetite Feelings and Gastric Emptying Rates in Lean and Non-Diabetic Obese Participants: A Randomized, Double-Blind, Parallel-Group Trial. PLoS One. 2016 Nov 22;11(11):e0166758. doi: 10.1371/journal.pone.0166758. eCollection 2016. |
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| 75 g Glucose | Placebo Comparator | 75 g Glucose in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube |
|
| Tap water | Placebo Comparator | 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube |
|
| Dietary Supplement |
|
| 1.56 g L-Leucine | Dietary Supplement |
|
| 50 g Xylitol | Dietary Supplement |
|
| 75 g Erythritol | Dietary Supplement |
|
| 75 g Glucose | Dietary Supplement |
|
| 300 mL tap water | Dietary Supplement |
|
| 50 mg 13C-sodium acetate | Other |
|
| ID | Term |
|---|---|
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D014364 | Tryptophan |
| D007930 | Leucine |
| D014993 | Xylitol |
| D004896 | Erythritol |
| D005947 | Glucose |
| ID | Term |
|---|---|
| D024322 | Amino Acids, Aromatic |
| D000598 | Amino Acids, Cyclic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D000601 | Amino Acids, Essential |
| D000597 | Amino Acids, Branched-Chain |
| D013402 | Sugar Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D002241 | Carbohydrates |
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
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