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The objective of this study is to examine gastric emptying and satiety hormones after oral glucose stimulation in 2 different concentrations in normal-weight and obese patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Glucose 10g | Active Comparator | 10g Glucose in 200ml tap water given orally (plus 50 mg 13C-sodium acetate)via nasogastric tube |
|
| Glucose 25g | Active Comparator | 25g Glucose in 200ml tap water given orally (plus 50 mg 13C-sodium acetate)via nasogastric tube |
|
| Placebo | Placebo Comparator | intragastric tap water |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Dietary Supplement |
| ||
| Glucose 25g |
| Measure | Description | Time Frame |
|---|---|---|
| Effect of different oral glucose loads on secretion of satiation hormones | Plasma concentrations of glucose, insulin, glucagon, ghrelin, GLP-1, PYY and CCK are measured | 240min. |
| Measure | Description | Time Frame |
|---|---|---|
| Effect of different oral glucose loads on gastric emptying | measured by C13 breath test | 240min. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Christoph Beglinger, Prof | University Hospital, Basel, Switzerland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Basel | Basel | CH-4031 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26942445 | Derived | Meyer-Gerspach AC, Cajacob L, Riva D, Herzog R, Drewe J, Beglinger C, Wolnerhanssen BK. Mechanisms Regulating Insulin Response to Intragastric Glucose in Lean and Non-Diabetic Obese Subjects: A Randomized, Double-Blind, Parallel-Group Trial. PLoS One. 2016 Mar 4;11(3):e0150803. doi: 10.1371/journal.pone.0150803. eCollection 2016. |
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| ID | Term |
|---|---|
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D005947 | Glucose |
| ID | Term |
|---|---|
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |
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| Glucose 10g | Dietary Supplement |
|