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The objective is to investigate neuro-anatomical correlates of gastrointestinal taste stimulation by means of functional MRI before and after bariatric surgery. Intragastric administration of glucose, monosodium glutamate, chloroquine and placebo is followed by functional brain MRI in obese humans before and 3 months after surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo preoperative | Placebo Comparator | Single intragastric instillation of 200ml tap water via nasogastric tube |
|
| Placebo postoperative | Placebo Comparator | Single intragastric instillation of 200ml tap water via nasogastric tube |
|
| Glucose preoperative | Active Comparator | Single intragastric instillation of 200ml tap water with 25g glucose via nasogastric tube |
|
| Glucose postoperative | Active Comparator | Single intragastric instillation of 200ml tap water with 25g glucose via nasogastric tube |
|
| Monosodium glutamate preoperative | Active Comparator | Single intragastric instillation of 200ml tap water with 1g monosodium glutamate via nasogastric tube |
|
| Monosodium glutamate postoperative |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Dietary Supplement | Tap water 200ml |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Effect of tastants on cerebral blood flow measured by functional brain MRI | changes from baseline to one hour after treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Effect of tastants plasma glucagon-like peptide (GLP-1) concentrations | changes from baseline to one hour after treatment | |
| Effect of tastants plasma ghrelin concentrations | changes from baseline to one hour after treatment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Bettina Wölnerhanssen, Dr | Contact | bettina.woelnerhanssen@usb.ch |
| Name | Affiliation | Role |
|---|---|---|
| Christoph Beglinger, Prof | University Basel | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hopital Basel | Recruiting | Basel | Switzerland |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D005947 | Glucose |
| D012970 | Sodium Glutamate |
| D011803 | Quinine |
| ID | Term |
|---|---|
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |
| D018698 |
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| Active Comparator |
Single intragastric instillation of 200ml tap water with 1g monosodium glutamate via nasogastric tube |
|
| Quinine preoperative | Active Comparator | Single intragastric instillation of 200ml tap water with 17mg quinine via nasogastric tube |
|
| Quinine postoperative | Active Comparator | Single intragastric instillation of 200ml tap water with 17mg quinine via nasogastric tube |
|
| Glucose |
| Dietary Supplement |
25g Glucose in 200ml tap water |
|
| Monosodium glutamate | Dietary Supplement | 1g monosodium glutamate in 200ml tap water |
|
| Quinine | Dietary Supplement | 17mg quinine in 200ml tap water |
|
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| Glutamic Acid |
| D005971 | Glutamates |
| D024342 | Amino Acids, Acidic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D000600 | Amino Acids, Dicarboxylic |
| D002930 | Cinchona Alkaloids |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D011812 | Quinuclidines |
| D006572 | Heterocyclic Compounds, Bridged-Ring |
| D011804 | Quinolines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |