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| Name | Class |
|---|---|
| NeuroPace | INDUSTRY |
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This study is designed to identify brain activity associated with good memory in subjects with a chronically implanted RNS® device and to study the effects of therapeutic stimulation for epilepsy on memory. This will be accomplished through analysis of ECoG data collected during memory encoding for short and long-term free recall as well as during navigation tasks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| RNS® Neurostimulator | Experimental | Subjects with pharmaceutically intractable seizures who have been implanted with a RNS® Neurostimulator. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| electrical stimulation | Other | Stimulation applied will be within parameters commonly used for the treatment of epilepsy during periods of encoding, recall, and memory maintenance . |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of words recalled with and without stimulation. | This study is designed to study the effects of therapeutic stimulation for epilepsy on memory. This outcome will be assessed by free recall language and memory tasks. | 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in the power spectrum of ECoG data with an increase of recalled words. | This study is designed to identify brain activity associated with good memory in subjects with a chronically implanted RNS® device. This outcome will be assessed by free recall language and memory tasks. | 30 days |
| Proportion of words recalled during times of interictal activity. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Barbara C Jobst, MD | Dartmouth-Hitchcock Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dartmouth-Hitchcock Medical Center in Lebanon, NH | Lebanon | New Hampshire | 03766 | United States |
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| ID | Term |
|---|---|
| D004827 | Epilepsy |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D004558 | Electric Stimulation |
| ID | Term |
|---|---|
| D010812 | Physical Stimulation |
| D008919 | Investigative Techniques |
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This study is designed to investigate the effects of IEDs on spatial, long-term, and short-term memory. This will be assessed by free recall language and memory tasks. |
| 30 days |
| Proportion of navigation challenges recalled successfully with and without stimulation. | This outcome will be assessed by real-world and virtual navigation tasks. | 30 days |