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| ID | Type | Description | Link |
|---|---|---|---|
| U01NS117838 | U.S. NIH Grant/Contract | View source | |
| R01MH124761 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Neurological Disorders and Stroke (NINDS) | NIH |
| National Institute of Mental Health (NIMH) | NIH |
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The purpose of this study is to understand the neural mechanisms that support real world spatial navigation in humans using deep brain recordings and stimulation during virtual reality (VR), augmented reality, and real world memory tasks. We will determine the cognitive (i.e., memory) and behavioral (i.e., body, head, eye position and movement) factors that modulate deep brain activity and the consequent effects of memory-enhancing deep brain stimulation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| RNS Participants | Experimental | Subjects with RNS implants. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Deep Brain Stimulation | Device | Deep brain stimulation will be used |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Spatial memory | Spatial memory will be measured using virtual, augmented and real-world spatial navigation tasks where participants will be asked to navigate a previously learned rout as well as if they recognize objects (i.e. landmarks) that appeared along the route (photos of seen landmarks vs unseen landmarks). | Throughout study completion, an average of 2-4 days per year |
| Memory performance change | Memory performance will be measured using excess path length, latency, and accuracy rate. | Throughout study completion, an average of 2-4 days per year |
| Oscillatory activity change | Changes in theta, gamma, and theta-gamma coupling will be measured both in relation to changes in memory performance on trials with and without deep brain stimulation as well as in relation to body, head, and eye position in a virtual, augmented, or real-world environment. | Throughout study completion, an average of 2-4 days per year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Gabriela Vilchez | Contact | 9196812577 | suthanalab@duke.edu | |
| Nanthia Suthana, PhD | Contact | 9196812577 | suthanalab@duke.edu |
| Name | Affiliation | Role |
|---|---|---|
| Nanthia Suthana, PhD | University of California, Los Angeles | Principal Investigator |
| Nanthia Suthana, PhD | Duke University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of California, Los Angeles | Recruiting | Los Angeles | California | 90024 | United States |
The data collected for this research represent a valuable resource to the scientific community, and the PIs will make them accessible to others, while respecting the special needs for confidentiality. All data will be anonymized before being provided to the scientific community. Researchers can also request access to the data under collaborative and co-authorship agreements prior to the end of the funding period or before publication. The results from the proposed project will also be shared at scientific meetings (local, national and international) as well via published manuscripts.
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All data will be provided by the time publication occurs or when the proposed funding period has ended.
Researchers can request access to the data under collaborative and co- authorship agreements prior to the end of the funding period or before publication.
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| ID | Term |
|---|---|
| D046690 | Deep Brain Stimulation |
| D011795 | Surveys and Questionnaires |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D013514 | Surgical Procedures, Operative |
| D003625 | Data Collection |
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| Memory and spatial navigation tasks |
| Behavioral |
Tasks may include walking around the room, on a treadmill, or in a controlled environment using VR (virtual reality) or AR (augmented reality) technology designed to simulate real-world navigation. Participants may also use Meta Ray-Ban glasses to capture new memories while recording neural activity. |
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| Physiological Signals | Behavioral | Physiological signals such as heart rate, respiration, and skin conductance will be monitored while completing lab tasks. Motion capture and eye-tracking may also be used. |
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| Questionnaires and Assessments | Behavioral | Participants complete questionnaires and assessments to assess subjective emotional experience. |
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| Duke University | Recruiting | Durham | North Carolina | 27705 | United States |
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| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |