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This is a prospective, outcomes assessor-blinded, randomized study to evaluate the efficacy and safety of "Inject BMP(Injectable Ceramics Bone Graft Substitute Containing rhBMP-2)" for socket preservation after extraction of a single-rooted tooth, compared to ExcelOS-inject(Injectable Ceramics Bone Graft Substitute).
Inject BMP is Injectable Ceramics Bone Graft Substitute(ExcelOS-inject) containing rhBMP-2. Recombinant human Bone morphogenetic protein 2 (rhBMP-2) stimulates the production of bone.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Inject BMP | Experimental | ExcelOS-inject containing rhBMP-2 |
|
| ExcelOS-inject | Active Comparator | ExcelOS-inject without rhBMP-2 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Inject BMP | Device | Injection of ExcelOS-inject(beta-TCP) containing rhBMP-2. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| compared the changed height and standard height by computed tomography. | at 12 weeks after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Soon Jung Hwang, Ph.D | Seoul National University Dental Hospital | Principal Investigator |
| Jong-Rak Hong, Ph.D | Samsung Medical Center | Principal Investigator |
| Hee-Kyun Oh, Ph.D | Chonnam National University | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34928477 | Derived | Han JJ, Chang AR, Ahn J, Jung S, Hong J, Oh HK, Hwang SJ. Efficacy and safety of rhBMP/beta-TCP in alveolar ridge preservation: a multicenter, randomized, open-label, comparative, investigator-blinded clinical trial. Maxillofac Plast Reconstr Surg. 2021 Dec 20;43(1):42. doi: 10.1186/s40902-021-00328-0. |
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| ExcelOS-inject |
| Device |
Injection of ExcelOS-inject(beta-TCP) without rhBMP-2. |
|