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The goal of this randomized clinical trial is to assess whether β-TCP (Beta-Tricalcium Phosphate) improves alveolar ridge preservation (ARP) in patients who need tooth extraction. The main question it aims to answer is whether using β-TCP for alveolar ridge preservation has a positive effect on bone volume compared with natural healing.
The main questions it aims to answer are:
Does β-TCP improve ridge preservation compared with natural healing?
Researchers will compare β-TCP grafted sockets to natural healing sockets to see if β-TCP better preserves ridge volume.
Participants will:
Have a tooth indicated for extraction.
Be assigned to either β-TCP or natural healing.
Undergo CBCT (Cone Beam Computed Tomography) and intra-oral scanning after extraction and after six months of healing to measure horizontal and vertical resorption and bone density.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Neocement Inject P® (Beta-Tricalcium Phosphate) | Experimental | After tooth extraction the socket will be grafted with Neocement Inject P® (Beta-Tricalcium Phosphate). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neocement Inject P® (Beta-Tricalcium Phosphate) | Device | After tooth extraction the socket will be grafted with Neocement Inject P® (Beta-Tricalcium Phosphate). |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in alveolar ridge volume after tooth extraction | Change in alveolar ridge volume after tooth extraction on sockets grafted with Beta-Tricalcium Phosphate | From enrollment to the end of treatment at 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Angel Lobito, Masters' in Dentistry | Contact | 00351924347050 | alobito@egasmoniz.edu.pt |
| Name | Affiliation | Role |
|---|---|---|
| João Botelho, PhD in Biomedical Sciences | Clinical Research Unit (CRU), Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinica Dentária Egas Moniz | Recruiting | Caparica | Monte Da Caparica | 2829-511 | Portugal |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37765676 | Background | Mishchenko O, Yanovska A, Kosinov O, Maksymov D, Moskalenko R, Ramanavicius A, Pogorielov M. Synthetic Calcium-Phosphate Materials for Bone Grafting. Polymers (Basel). 2023 Sep 19;15(18):3822. doi: 10.3390/polym15183822. |
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| ID | Term |
|---|---|
| D016301 | Alveolar Bone Loss |
| ID | Term |
|---|---|
| D001862 | Bone Resorption |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D055093 | Periodontal Atrophy |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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